Mineralys Therapeutics, Inc.

1. Represents restricted stock units (RSUs) that were granted to the reporting person for no additional cash consideration, each of which represents a contingent right to receive one share of common stock upon vesting. The RSUs vest in annual installments over a period of four years, with 1/4th of the total shares underlying the RSU vesting on each one-year anniversary of February 19, 2026, the date of grant.

2. The stock option vests as to 25% of the underlying shares on the first anniversary of April 21, 2025, the date of grant, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

3. The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following February 19, 2026, the date of grant.