Form 4 • Statement of Changes in Beneficial Ownership
Type
Sell
Net shares
-6,659
% of shares
-10.18%
Amount (USD)
$530,986
Insider confidence score
25.0 out of 100
Positive
Negative
Security
Common Stock
Action
Sell
Date
2026-03-03
Code
S
Net shares
-4,096.0
Price per Share
$79.36
Amount (USD)
$325,058.56
Acquired/Disposed
Disposed
Shares Owned Before
45,413.0
Shares Owned After
41,317.0
Security
Common Stock
Action
Exercise
Date
2026-03-03
Code
M
Net shares
+820.0
Price per Share
$56.78
Amount (USD)
$46,559.60
Acquired/Disposed
Acquired
Shares Owned Before
4,772.0
Shares Owned After
5,592.0
Security
Common Stock
Action
Exercise
Date
2026-03-03
Code
M
Net shares
+879.0
Price per Share
$32.60
Amount (USD)
$28,655.40
Acquired/Disposed
Acquired
Shares Owned Before
5,592.0
Shares Owned After
6,471.0
Security
Common Stock
Action
Sell
Date
2026-03-03
Code
S
Net shares
-2,088.0
Price per Share
$80.41
Amount (USD)
$167,891.70
Acquired/Disposed
Disposed
Shares Owned Before
6,471.0
Shares Owned After
4,383.0
Security
Common Stock
Action
Sell
Date
2026-03-03
Code
S
Net shares
-36.0
Price per Share
$81.01
Amount (USD)
$2,916.36
Acquired/Disposed
Disposed
Shares Owned Before
4,383.0
Shares Owned After
4,347.0
Security
Common Stock
Action
Exercise
Date
2026-03-04
Code
M
Net shares
+238.0
Price per Share
$56.78
Amount (USD)
$13,513.64
Acquired/Disposed
Acquired
Shares Owned Before
4,347.0
Shares Owned After
4,585.0
Security
Common Stock
Action
Sell
Date
2026-03-04
Code
S
Net shares
-238.0
Price per Share
$80.00
Amount (USD)
$19,040.00
Acquired/Disposed
Disposed
Shares Owned Before
4,585.0
Shares Owned After
4,347.0
Security
Common Stock
Action
Exercise
Date
2026-03-04
Code
M
Net shares
+201.0
Price per Share
$32.60
Amount (USD)
$6,552.60
Acquired/Disposed
Acquired
Shares Owned Before
4,347.0
Shares Owned After
4,548.0
Security
Common Stock
Action
Sell
Date
2026-03-04
Code
S
Net shares
-201.0
Price per Share
$80.00
Amount (USD)
$16,080.00
Acquired/Disposed
Disposed
Shares Owned Before
4,548.0
Shares Owned After
4,347.0
Security
Non-Qualified Stock Option (right to buy)
Action
Exercise
Date
2026-03-03
Code
M
Net shares
-879.0
Acquired/Disposed
Disposed
Shares Owned Before
2,849.0
Shares Owned After
1,970.0
Security
Non-Qualified Stock Option (right to buy)
Action
Exercise
Date
2026-03-04
Code
M
Net shares
-201.0
Acquired/Disposed
Disposed
Shares Owned Before
1,970.0
Shares Owned After
1,769.0
Security
Non-Qualified Stock Option (right to buy)
Action
Exercise
Date
2026-03-03
Code
M
Net shares
-820.0
Acquired/Disposed
Disposed
Shares Owned Before
4,924.0
Shares Owned After
4,104.0
Security
Non-Qualified Stock Option (right to buy)
Action
Exercise
Date
2026-03-04
Code
M
Net shares
-238.0
Acquired/Disposed
Disposed
Shares Owned Before
4,104.0
Shares Owned After
3,866.0
1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 25, 2025.
2. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting persons spouse on November 25, 2025.
3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.00 to $80.94 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.
ℹ️ Filed under Rule 10b5-1 trading plan
This page is for informational purposes only. While we strive for accuracy, the summary may contain inaccuracies or omissions. Please refer to the official SEC filing for authoritative information. Open the SEC filing.