IONIS PHARMACEUTICALS INC

IONS

Form 4 • Statement of Changes in Beneficial Ownership

SEC Accession Number: 0000874015-26-000138
Filing date: Mar 5, 2026
Earliest execution date: Mar 3, 2026
Reporting Owners: LOSCALZO JOSEPH (Director)

Summary

Type

Sell

Net shares

-1,032

% of shares

-1.40%

Amount (USD)

$82,832

Insider confidence score

46.3 out of 100

Positive

  • Under Rule 10b5-1 trading plan

Negative

  • Moderate scheduled sell (<2% of shares)
  • Significant sell amount ($50K+)

Stock transactions

Transaction 1

Security

Common Stock

Action

Exercise

Date

2026-03-03

Code

M

Net shares

+832.0

Price per Share

$38.06

Amount (USD)

$31,665.92

Acquired/Disposed

Acquired

Shares Owned Before

36,330.0

Shares Owned After

37,162.0

Transaction 2

Security

Common Stock

Action

Sell

Date

2026-03-03

Code

S

Net shares

-832.0

Price per Share

$80.33

Amount (USD)

$66,832.81

Acquired/Disposed

Disposed

Shares Owned Before

37,162.0

Shares Owned After

36,330.0

Transaction 3

Security

Common Stock

Action

Exercise

Date

2026-03-04

Code

M

Net shares

+200.0

Price per Share

$38.06

Amount (USD)

$7,612.00

Acquired/Disposed

Acquired

Shares Owned Before

36,330.0

Shares Owned After

36,530.0

Transaction 4

Security

Common Stock

Action

Sell

Date

2026-03-04

Code

S

Net shares

-200.0

Price per Share

$80.00

Amount (USD)

$16,000.00

Acquired/Disposed

Disposed

Shares Owned Before

36,530.0

Shares Owned After

36,330.0

Derivative Transactions

Transaction 1

Security

Non-Qualified Stock Option (right to buy)

Action

Exercise

Date

2026-03-03

Code

M

Net shares

-832.0

Acquired/Disposed

Disposed

Shares Owned Before

12,000.0

Shares Owned After

11,168.0

Transaction 2

Security

Non-Qualified Stock Option (right to buy)

Action

Exercise

Date

2026-03-04

Code

M

Net shares

-200.0

Acquired/Disposed

Disposed

Shares Owned Before

11,168.0

Shares Owned After

10,968.0

Filing's footnotes

1. Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on November 18, 2025.

2. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.035 to $81.01 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

ℹ️ Filed under Rule 10b5-1 trading plan

This page is for informational purposes only. While we strive for accuracy, the summary may contain inaccuracies or omissions. Please refer to the official SEC filing for authoritative information. Open the SEC filing.