2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| EcoR1 Capital, LLC | Director | 7,880,094 | Jan 2, 2025 |
| Nodelman Oleg | Director | 7,880,094 | Jan 2, 2025 |
| Novo A/S | 10% Owner | 1,936,604 | Aug 21, 2017 |
| Heron Patrick J | 10% Owner | 973,612 | May 15, 2018 |
| Every Nathan R | 10% Owner | 973,612 | May 15, 2018 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 11, 2026 | Feb 13, 2026 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 10.0 | -10,000 | -43.79% | ✓ | $540K |
| Jan 15, 2026 | Jan 16, 2026 | Marquet Magda | Director | Sell | 20.0 | -11,000 | -52.56% | ✗ | $530.5K |
| Jan 7, 2026 | Jan 9, 2026 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -3,650 | -7.98% | ✗ | $163.2K |
| Jan 7, 2026 | Jan 9, 2026 | MULROY DENNIS | CFO | Sell | 42.5 | -2,515 | -10.32% | ✗ | $112.4K |
| Jan 7, 2026 | Jan 9, 2026 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 42.5 | -2,210 | -14.69% | ✗ | $98.8K |
| Jan 7, 2026 | Jan 9, 2026 | Faga Daniel | CEO | Sell | 40.0 | -14,281 | -2.89% | ✗ | $638.5K |
| Jan 6, 2026 | Jan 8, 2026 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 10.0 | -9,639 | -51.28% | ✓ | $439.2K |
| Jan 6, 2026 | Jan 8, 2026 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -2,235 | -5.67% | ✗ | $100.8K |
| Jan 6, 2026 | Jan 8, 2026 | Faga Daniel | CEO | Sell | 40.0 | -9,202 | -1.93% | ✗ | $415.1K |
| Jan 6, 2026 | Jan 8, 2026 | MULROY DENNIS | CFO | Sell | 42.5 | -1,908 | -9.75% | ✗ | $86.1K |
| Jan 6, 2026 | Jan 8, 2026 | FENTON DENNIS M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | Jain Rita | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | Marquet Magda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | RENTON HOLLINGS | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | Ware J. Anthony | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2026 | Jan 6, 2026 | Faga Daniel | CEO | Sell | 40.0 | -15,309 | -3.23% | ✗ | $662.3K |
| Jan 3, 2026 | Jan 6, 2026 | MULROY DENNIS | CFO | Sell | 42.5 | -3,363 | -19.01% | ✗ | $145.5K |
| Jan 3, 2026 | Jan 6, 2026 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -4,219 | -11.24% | ✗ | $182.5K |
| Jan 3, 2026 | Jan 6, 2026 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 42.5 | -2,983 | -18.38% | ✗ | $129K |
| Dec 23, 2025 | Dec 23, 2025 | Ware J. Anthony | Director | Sell | 22.5 | -3,900 | -28.82% | ✗ | $193.3K |
| Dec 23, 2025 | Dec 23, 2025 | Schmid John P. | Director | Sell | 20.0 | -11,068 | -17.48% | ✗ | $564.5K |
| Dec 22, 2025 | Dec 23, 2025 | Lizzul Paul F. | Chief Medical Officer | Sell | 33.8 | -1,500 | -5.27% | ✓ | $75K |
| Dec 22, 2025 | Dec 23, 2025 | MULROY DENNIS | CFO | Sell | 10.0 | -10,000 | -51.54% | ✓ | $500K |
| Dec 22, 2025 | Dec 23, 2025 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 10.0 | -10,000 | -52.78% | ✓ | $510K |
| Dec 16, 2025 | Dec 18, 2025 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 5.0 | -22,641 | -35.91% | ✓ | $1M |
| Dec 16, 2025 | Dec 18, 2025 | MULROY DENNIS | CFO | Sell | 7.5 | -15,725 | -62.58% | ✓ | $705.3K |
| Sep 30, 2025 | Oct 1, 2025 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 10.0 | -8,240 | -47.55% | ✓ | $239K |
| Sep 15, 2025 | Sep 17, 2025 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 8, 2025 | Aug 12, 2025 | RENTON HOLLINGS | Director | Sell | 10.0 | -10,231 | -67.33% | ✓ | $200.7K |
| Jul 2, 2025 | Jul 3, 2025 | RENTON HOLLINGS | Director | Sell | 7.5 | -20,925 | -80.82% | ✓ | $493.2K |
| Jun 18, 2025 | Jun 20, 2025 | FENTON DENNIS M | Director | Sell | 10.0 | -3,015 | -37.78% | ✓ | $72.3K |
| Jun 18, 2025 | Jun 20, 2025 | RENTON HOLLINGS | Director | Sell | 10.0 | -3,015 | -37.78% | ✓ | $72.3K |
| Jun 15, 2025 | Jun 17, 2025 | Jain Rita | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | FENTON DENNIS M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Marquet Magda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | RENTON HOLLINGS | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Ware J. Anthony | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 25, 2025 | Mar 27, 2025 | Schmid John P. | Director | Buy | 95.0 | +11,068 | 23.94% | ✗ | $201.2K |
| Jan 13, 2025 | Jan 15, 2025 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 7, 2025 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -6,597 | -12.22% | ✗ | $97.9K |
| Jan 3, 2025 | Jan 7, 2025 | MULROY DENNIS | CFO | Sell | 42.5 | -5,461 | -18.28% | ✗ | $81.2K |
| Jan 3, 2025 | Jan 7, 2025 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 42.5 | -5,211 | -21.81% | ✗ | $77.6K |
| Jan 7, 2025 | Jan 7, 2025 | FENTON DENNIS M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | Jain Rita | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | Marquet Magda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | RENTON HOLLINGS | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2025 | Jan 7, 2025 | Ware J. Anthony | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 7, 2025 | Faga Daniel | CEO | Sell | 40.0 | -19,420 | -2.20% | ✗ | $288K |
| Dec 30, 2024 | Jan 2, 2025 | EcoR1 Capital, LLC | Director | Buy | 87.5 | +85,098 | 1.09% | ✗ | $1.1M |
| Nov 29, 2024 | Dec 3, 2024 | RENTON HOLLINGS | Director | Sell | 7.5 | -10,000 | -83.68% | ✓ | $250K |
| Sep 23, 2024 | Sep 24, 2024 | Lizzul Paul F. | Chief Medical Officer | Sell | 28.8 | -1,500 | -8.88% | ✓ | $58K |
| Sep 15, 2024 | Sep 17, 2024 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 14, 2024 | Sep 17, 2024 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 7.5 | -12,500 | -39.96% | ✓ | $492.5K |
| Sep 14, 2024 | Sep 17, 2024 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -2,220 | -12.60% | ✗ | $86.4K |
| Sep 14, 2024 | Sep 17, 2024 | MULROY DENNIS | CFO | Sell | 7.5 | -12,220 | -56.29% | ✓ | $487.7K |
| Aug 14, 2024 | Aug 16, 2024 | Lizzul Paul F. | Chief Medical Officer | Sell | 25.0 | -2,000 | -14.69% | ✓ | $80K |
| Aug 14, 2024 | Aug 16, 2024 | EcoR1 Capital, LLC | 10% Owner | Buy | 93.8 | +273,972 | 3.64% | ✗ | $10M |
| Jul 22, 2024 | Jul 24, 2024 | Faga Daniel | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 22, 2024 | Jul 24, 2024 | Lizzul Paul F. | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 22, 2024 | Jul 24, 2024 | MULROY DENNIS | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 22, 2024 | Jul 24, 2024 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 18, 2024 | Jul 19, 2024 | Lizzul Paul F. | Chief Medical Officer | Sell | 25.0 | -1,500 | -11.43% | ✓ | $52.5K |
| Jul 15, 2024 | Jul 17, 2024 | RENTON HOLLINGS | Director | Sell | 7.5 | -10,000 | -83.68% | ✓ | $306.4K |
| Jun 21, 2024 | Jun 24, 2024 | FENTON DENNIS M | Director | Sell | 13.8 | -1,950 | -50.00% | ✓ | $45.2K |
| Jun 15, 2024 | Jun 18, 2024 | FENTON DENNIS M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2024 | Jun 18, 2024 | Marquet Magda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2024 | Jun 18, 2024 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2024 | Jun 18, 2024 | Ware J. Anthony | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2024 | Jun 18, 2024 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2024 | Jun 18, 2024 | RENTON HOLLINGS | Director | Sell | 13.8 | -1,950 | -50.00% | ✓ | $45.2K |
| Jun 15, 2024 | Jun 18, 2024 | Jain Rita | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 22, 2024 | May 24, 2024 | MULROY DENNIS | CFO | Sell | 13.8 | -1,500 | -60.88% | ✓ | $35.6K |
| Mar 22, 2024 | Mar 26, 2024 | Faga Daniel | CEO | Sell | 35.0 | -496,381 | -55.27% | ✗ | $10.9M |
| Feb 16, 2024 | Feb 21, 2024 | LOUMEAU ERIC J | CHIEF LEGAL OFFICER | Sell | 10.0 | -5,000 | -60.68% | ✓ | $125K |
| Jan 30, 2024 | Feb 1, 2024 | MULROY DENNIS | CFO | Sell | 10.0 | -3,065 | -76.07% | ✓ | $72.4K |
| Jan 6, 2024 | Jan 9, 2024 | Lizzul Paul F. | Chief Medical Officer | Sell | 42.5 | -2,554 | -20.15% | ✗ | $55.7K |
| Jan 6, 2024 | Jan 9, 2024 | LOUMEAU ERIC J | Chief Legal Officer | Sell | 42.5 | -2,305 | -41.57% | ✗ | $50.3K |
| Jan 6, 2024 | Jan 9, 2024 | MULROY DENNIS | CFO | Sell | 46.3 | -2,180 | -35.11% | ✗ | $47.5K |
| Jan 6, 2024 | Jan 9, 2024 | Faga Daniel | CEO | Sell | 45.0 | -6,866 | -0.76% | ✗ | $149.7K |
| Jan 3, 2024 | Jan 5, 2024 | Jain Rita | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Lizzul Paul F. | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Marquet Magda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Orwin John A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | RENTON HOLLINGS | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | LOUMEAU ERIC J | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | MULROY DENNIS | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | FENTON DENNIS M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Faga Daniel | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2024 | Jan 5, 2024 | Ware J. Anthony | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 22, 2023 | Nov 27, 2023 | LOUMEAU ERIC J | Chief Legal Officer | Sell | 13.8 | -882 | -100.00% | ✓ | $12.5K |
| Sep 14, 2023 | Sep 18, 2023 | Lizzul Paul F. | Chief Medical Officer | Sell | 46.3 | -2,105 | -24.39% | ✗ | $41K |
| Sep 14, 2023 | Sep 18, 2023 | LOUMEAU ERIC J | Chief Legal Officer | Sell | 10.0 | -6,000 | -87.18% | ✓ | $116.2K |
| Sep 14, 2023 | Sep 18, 2023 | MULROY DENNIS | CFO | Sell | 10.0 | -6,000 | -86.16% | ✓ | $116.2K |