2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Baker Bros. Advisors Lp | 10% Owner | 14,270,530 | Nov 6, 2015 |
| Baker Bros. Advisors (GP) LLC | 10% Owner | 14,270,530 | Nov 6, 2015 |
| Baker Felix | 10% Owner | 14,270,530 | Nov 6, 2015 |
| Baker Julian | 10% Owner | 14,270,530 | Nov 6, 2015 |
| Stonehouse Jon P | Director | 750,250 | Dec 23, 2024 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 27, 2026 | Mar 3, 2026 | Milne Jill C. | Director | Neutral | 82.5 | +528 | 3.55% | ✗ | - |
| Feb 27, 2026 | Mar 3, 2026 | Stonehouse Jon P | Director | Sell | 23.8 | -305,574 | -10.07% | ✓ | $2.6M |
| Feb 27, 2026 | Mar 3, 2026 | MILANO VINCENT | Director | Neutral | 67.5 | +848 | 0.93% | ✗ | - |
| Feb 27, 2026 | Mar 3, 2026 | Frank Steven | Director | Neutral | 85.0 | +1,285 | 7.29% | ✗ | - |
| Feb 27, 2026 | Mar 3, 2026 | McKee Amy E | Director | Neutral | 77.5 | +642 | 1.54% | ✗ | - |
| Jan 23, 2026 | Jan 27, 2026 | Milne Jill C. | Director | Neutral | 90.0 | +14,854 | 100.00% | ✗ | - |
| Jan 27, 2026 | Milne Jill C. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 9, 2026 | Dullinger Ronald | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 19, 2025 | Dec 23, 2025 | Stonehouse Jon P | CEO | Sell | 40.0 | -61,793 | -4.22% | ✗ | $457.9K |
| Dec 19, 2025 | Dec 23, 2025 | Barnes Alane P | Chief Legal Officer | Sell | 28.8 | -38,675 | -8.84% | ✓ | $291.8K |
| Dec 19, 2025 | Dec 23, 2025 | Gayer Charles K | President | Sell | 42.5 | -11,477 | -1.29% | ✗ | $85K |
| Dec 18, 2025 | Dec 19, 2025 | Stonehouse Jon P | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 17, 2025 | Dec 19, 2025 | Gayer Charles K | President | Neutral | 90.0 | +471,000 | 112.46% | ✗ | - |
| Dec 17, 2025 | Dec 19, 2025 | Barnes Alane P | Chief Legal Officer | Neutral | 90.0 | +121,700 | 38.55% | ✗ | - |
| Dec 17, 2025 | Dec 19, 2025 | Ghias Babar | CFO | Neutral | 90.0 | +121,700 | 82.79% | ✗ | - |
| Dec 12, 2025 | Dec 16, 2025 | Gayer Charles K | President | Sell | 42.5 | -8,181 | -1.92% | ✗ | $61.9K |
| Dec 12, 2025 | Dec 16, 2025 | Barnes Alane P | Chief Legal Officer | Sell | 28.8 | -29,750 | -8.61% | ✓ | $226.9K |
| Dec 12, 2025 | Dec 16, 2025 | Stonehouse Jon P | CEO | Sell | 42.5 | -27,368 | -1.83% | ✗ | $207.2K |
| Dec 1, 2025 | Dec 3, 2025 | Barnes Alane P | Chief Legal Officer | Sell | 5.0 | -161,680 | -31.88% | ✓ | $1.2M |
| Nov 28, 2025 | Dec 2, 2025 | McKee Amy E | Director | Neutral | 77.5 | +783 | 1.91% | ✗ | - |
| Nov 28, 2025 | Dec 2, 2025 | Frank Steven | Director | Neutral | 85.0 | +1,566 | 9.76% | ✗ | - |
| Nov 28, 2025 | Dec 2, 2025 | MILANO VINCENT | Director | Neutral | 67.5 | +783 | 0.87% | ✗ | - |
| Nov 13, 2025 | Nov 17, 2025 | SANDERS MACHELLE | Director | Sell | 15.0 | -9,600 | -23.86% | ✓ | $68.5K |
| Aug 29, 2025 | Sep 3, 2025 | McKee Amy E | Director | Neutral | 77.5 | +676 | 1.68% | ✗ | - |
| Aug 29, 2025 | Sep 3, 2025 | Frank Steven | Director | Neutral | 85.0 | +1,353 | 9.20% | ✗ | - |
| Aug 29, 2025 | Sep 3, 2025 | MILANO VINCENT | Director | Neutral | 67.5 | +676 | 0.75% | ✗ | - |
| Aug 13, 2025 | Aug 15, 2025 | HEGGIE THERESA | Director | Sell | 20.0 | -70,000 | -51.72% | ✗ | $595.9K |
| Jul 24, 2025 | Jul 28, 2025 | Ghias Babar | CFO | Neutral | 90.0 | +147,000 | 100.00% | ✗ | - |
| Jul 11, 2025 | Ghias Babar | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 12, 2025 | Jun 16, 2025 | SANDERS MACHELLE | Director | Neutral | 90.0 | +12,500 | 45.06% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | MILANO VINCENT | Director | Neutral | 90.0 | +12,500 | 16.18% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | McKee Amy E | Director | Neutral | 90.0 | +12,500 | 44.91% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | LEVIN ALAN G | Director | Neutral | 90.0 | +12,500 | 24.14% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Hutson Nancy J | Director | Neutral | 90.0 | +12,500 | 14.43% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | HEGGIE THERESA | Director | Neutral | 90.0 | +12,500 | 23.65% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Galson Steven K | Director | Neutral | 90.0 | +12,500 | 21.41% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Frank Steven | Director | Neutral | 90.0 | +12,500 | 568.44% | ✗ | - |
| May 30, 2025 | Jun 3, 2025 | MILANO VINCENT | Director | Neutral | 67.5 | +523 | 0.68% | ✗ | - |
| May 30, 2025 | Jun 3, 2025 | Frank Steven | Director | Neutral | 90.0 | +333 | 17.85% | ✗ | - |
| May 2, 2025 | May 6, 2025 | Frank Steven | Director | Neutral | 90.0 | +1,866 | 100.00% | ✗ | - |
| May 6, 2025 | Frank Steven | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 31, 2025 | Apr 2, 2025 | Thackray Helen M. | Chief R&D Officer | Sell | 42.5 | -7,525 | -1.96% | ✗ | $56.4K |
| Feb 28, 2025 | Mar 4, 2025 | MILANO VINCENT | Director | Neutral | 67.5 | +653 | 0.86% | ✗ | - |
| Dec 19, 2024 | Dec 23, 2024 | Gayer Charles K | Chief Commercial Officer | Sell | 91.3 | +123,489 | 41.16% | ✗ | $18.2K |
| Dec 19, 2024 | Dec 23, 2024 | Thackray Helen M. | Chief R&D Officer | Sell | 91.3 | +119,854 | 45.23% | ✗ | $45K |
| Dec 19, 2024 | Dec 23, 2024 | Doyle Anthony | CFO | Sell | 91.3 | +118,239 | 45.54% | ✗ | $18.2K |
| Dec 19, 2024 | Dec 23, 2024 | Barnes Alane P | Chief Legal Officer | Sell | 91.3 | +118,239 | 40.15% | ✗ | $18.2K |
| Dec 19, 2024 | Dec 23, 2024 | Stonehouse Jon P | CEO | Sell | 95.0 | +348,090 | 30.51% | ✗ | $103.5K |
| Dec 14, 2024 | Dec 17, 2024 | Gayer Charles K | Chief Commercial Officer | Sell | 42.5 | -8,251 | -2.68% | ✗ | $62.1K |
| Dec 14, 2024 | Dec 17, 2024 | Stonehouse Jon P | CEO | Sell | 42.5 | -27,525 | -2.36% | ✗ | $207.3K |
| Dec 14, 2024 | Dec 17, 2024 | Barnes Alane P | Chief Legal Officer | Sell | 42.5 | -8,613 | -2.84% | ✗ | $64.9K |
| Dec 14, 2024 | Dec 17, 2024 | Doyle Anthony | CFO | Sell | 42.5 | -7,890 | -2.95% | ✗ | $59.4K |
| Dec 14, 2024 | Dec 17, 2024 | Thackray Helen M. | Chief R&D Officer | Sell | 42.5 | -7,150 | -2.63% | ✗ | $53.8K |
| Dec 13, 2024 | Dec 16, 2024 | Hutson Nancy J | Director | Sell | 32.5 | -7,000 | -7.48% | ✓ | $52.8K |
| Nov 29, 2024 | Dec 2, 2024 | MILANO VINCENT | Director | Neutral | 67.5 | +750 | 1.00% | ✗ | - |
| Aug 30, 2024 | Sep 3, 2024 | MILANO VINCENT | Director | Neutral | 67.5 | +647 | 0.87% | ✗ | - |
| Jun 24, 2024 | Jun 25, 2024 | McKee Amy E | Director | Sell | 22.5 | -8,600 | -23.61% | ✗ | $54.4K |
| Jun 17, 2024 | Jun 17, 2024 | SANDERS MACHELLE | Director | Sell | 26.3 | -4,689 | -14.46% | ✗ | $28.1K |
| Jun 12, 2024 | Jun 14, 2024 | SANDERS MACHELLE | Director | Neutral | 90.0 | +6,820 | 26.63% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | MILANO VINCENT | Director | Neutral | 90.0 | +6,820 | 10.05% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | McKee Amy E | Director | Neutral | 90.0 | +6,820 | 23.03% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | LEVIN ALAN G | Director | Neutral | 90.0 | +6,820 | 15.17% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Hutson Nancy J | Director | Neutral | 85.0 | +6,820 | 7.86% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | HEGGIE THERESA | Director | Sell | 61.3 | +122 | 0.23% | ✗ | $40.9K |
| Jun 12, 2024 | Jun 14, 2024 | Galson Steven K | Director | Neutral | 90.0 | +6,820 | 13.23% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | ASELAGE STEVE | Director | Neutral | 90.0 | +6,820 | 10.36% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | ABERCROMBIE GEORGE B | Director | Neutral | 90.0 | +6,820 | 23.03% | ✗ | - |
| May 31, 2024 | Jun 3, 2024 | HEGGIE THERESA | Director | Neutral | 77.5 | +870 | 1.68% | ✗ | - |
| May 31, 2024 | Jun 3, 2024 | MILANO VINCENT | Director | Neutral | 77.5 | +870 | 1.30% | ✗ | - |
| May 30, 2024 | May 31, 2024 | LEVIN ALAN G | Director | Buy | 91.3 | +7,861 | 21.19% | ✗ | $50K |
| May 24, 2024 | May 29, 2024 | ASELAGE STEVE | Director | Buy | 83.8 | +2,500 | 3.95% | ✗ | $16K |
| May 20, 2024 | May 22, 2024 | Hutson Nancy J | Director | Buy | 86.3 | +5,000 | 6.11% | ✗ | $31.9K |
| May 20, 2024 | May 22, 2024 | MILANO VINCENT | Director | Buy | 95.0 | +15,000 | 28.85% | ✗ | $93.8K |
| May 14, 2024 | May 15, 2024 | Doyle Anthony | CFO | Buy | 95.0 | +36,300 | 15.75% | ✗ | $202.2K |
| May 14, 2024 | May 15, 2024 | Thackray Helen M. | Chief R&D Officer | Buy | 95.0 | +30,000 | 12.39% | ✗ | $175.8K |
| May 13, 2024 | May 15, 2024 | Galson Steven K | Director | Buy | 95.0 | +21,940 | 74.09% | ✗ | $120.5K |
| May 13, 2024 | May 15, 2024 | Barnes Alane P | Chief Legal Officer | Buy | 78.8 | +5,000 | 1.69% | ✗ | $27.7K |
| May 13, 2024 | May 15, 2024 | Stonehouse Jon P | CEO | Buy | 87.5 | +30,000 | 2.64% | ✗ | $166.5K |
| May 13, 2024 | May 15, 2024 | Gayer Charles K | Chief Commercial Officer | Buy | 95.0 | +30,000 | 10.81% | ✗ | $164.1K |
| Mar 31, 2024 | Apr 2, 2024 | Thackray Helen M. | Chief R&D Officer | Sell | 46.3 | -7,525 | -3.01% | ✗ | $38.2K |
| Feb 29, 2024 | Mar 4, 2024 | MILANO VINCENT | Director | Neutral | 77.5 | +999 | 1.96% | ✗ | - |
| Feb 29, 2024 | Mar 4, 2024 | HEGGIE THERESA | Director | Neutral | 77.5 | +999 | 1.96% | ✗ | - |
| Jan 3, 2024 | Jan 4, 2024 | Stonehouse Jon P | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 19, 2023 | Dec 20, 2023 | Thackray Helen M. | Chief R&D Officer | Sell | 46.3 | -5,580 | -2.19% | ✗ | $33.8K |
| Dec 19, 2023 | Dec 20, 2023 | Stonehouse Jon P | CEO | Sell | 42.5 | -14,089 | -1.23% | ✗ | $85.2K |
| Dec 19, 2023 | Dec 20, 2023 | Gayer Charles K | Chief Commercial Officer | Sell | 48.8 | -2,482 | -0.90% | ✗ | $15K |
| Dec 19, 2023 | Dec 20, 2023 | Doyle Anthony | CFO | Sell | 46.3 | -2,482 | -1.08% | ✗ | $15K |
| Dec 19, 2023 | Dec 20, 2023 | Barnes Alane P | Chief Legal Officer | Sell | 48.8 | -2,482 | -0.84% | ✗ | $15K |
| Dec 14, 2023 | Dec 18, 2023 | Thackray Helen M. | Chief R&D Officer | Sell | 91.3 | +47,969 | 23.14% | ✗ | $19.5K |
| Dec 14, 2023 | Dec 18, 2023 | Stonehouse Jon P | CEO | Sell | 95.0 | +113,908 | 11.01% | ✗ | $87.4K |
| Dec 14, 2023 | Dec 18, 2023 | Gayer Charles K | Chief Commercial Officer | Sell | 91.3 | +28,160 | 11.32% | ✗ | $37.6K |
| Dec 14, 2023 | Dec 18, 2023 | Doyle Anthony | CFO | Sell | 91.3 | +28,525 | 14.16% | ✗ | $35.2K |
| Dec 14, 2023 | Dec 18, 2023 | Barnes Alane P | Chief Legal Officer | Sell | 91.3 | +59,985 | 25.41% | ✗ | $25.8K |
| Nov 30, 2023 | Dec 1, 2023 | MILANO VINCENT | Director | Neutral | 77.5 | +956 | 1.91% | ✗ | - |
| Nov 30, 2023 | Dec 1, 2023 | HEGGIE THERESA | Director | Neutral | 77.5 | +956 | 1.92% | ✗ | - |
| Aug 31, 2023 | Sep 5, 2023 | MILANO VINCENT | Director | Neutral | 77.5 | +791 | 1.61% | ✗ | - |
| Aug 31, 2023 | Sep 5, 2023 | HEGGIE THERESA | Director | Neutral | 77.5 | +791 | 1.61% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | Stonehouse Jon P | CEO | Neutral | 27.5 | -25,000 | -2.36% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | LEVIN ALAN G | Director | Neutral | 90.0 | +16,745 | 82.31% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | LEE KENNETH B JR | Director | Neutral | 90.0 | +16,745 | 32.13% | ✗ | - |