2025Q4
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Marxe Austin W & Greenhouse David M | 10% Owner | 2,208,368 | Feb 3, 2015 |
| Chen Bihua | — | 530,000 | Sep 5, 2014 |
| Cormorant Asset Management, LP | — | 530,000 | Sep 5, 2014 |
| Cormorant Global Healthcare Master Fund, LP | — | 530,000 | Sep 5, 2014 |
| Cormorant Global Healthcare GP, LLC | — | 530,000 | Sep 5, 2014 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Dec 12, 2025 | Dec 16, 2025 | NEIS JOHN | Director | Sell | 27.5 | -198 | -95.19% | ✗ | $732 |
| Jul 2, 2025 | Jul 3, 2025 | CARUSO JAMES V | CEO | Buy | 91.3 | +10,000 | 610.50% | ✗ | $49.9K |
| Jul 2, 2025 | Jul 3, 2025 | Longcor Jarrod | COO | Buy | 91.3 | +10,000 | 361.27% | ✗ | $49.9K |
| Jul 2, 2025 | Jul 3, 2025 | Kolean Chad J | CFO | Buy | 91.3 | +5,000 | 352.61% | ✗ | $25K |
| Jan 10, 2025 | Mar 12, 2025 | Longcor Jarrod | COO | Buy | 90.0 | +30,000 | 56.45% | ✗ | $8.4K |
| Feb 14, 2025 | Feb 18, 2025 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | Longcor Jarrod | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 14, 2025 | Feb 18, 2025 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Longcor Jarrod | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Shustov Andrei | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Lea Darrell Shane | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2024 | Jun 18, 2024 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 8, 2023 | Dec 12, 2023 | Lea Darrell Shane | Chief Commercial Officer | Neutral | 90.0 | +39,599 | 100.00% | ✗ | - |
| Dec 8, 2023 | Dec 12, 2023 | Kolean Chad J | CFO | Neutral | 90.0 | +42,554 | 177308.33% | ✗ | - |
| Dec 8, 2023 | Dec 12, 2023 | Shustov Andrei | President | Neutral | 90.0 | +47,856 | 666.36% | ✗ | - |
| Dec 8, 2023 | Dec 12, 2023 | Longcor Jarrod | COO | Neutral | 90.0 | +42,927 | 420.28% | ✗ | - |
| Dec 8, 2023 | Dec 12, 2023 | CARUSO JAMES V | CEO | Neutral | 90.0 | +40,596 | 469.86% | ✗ | - |
| Jun 28, 2023 | Jun 28, 2023 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 28, 2023 | Jun 28, 2023 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 28, 2023 | Jun 28, 2023 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 28, 2023 | Jun 28, 2023 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 28, 2023 | Jun 28, 2023 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 15, 2023 | Mar 16, 2023 | Shustov Andrei | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 16, 2023 | Shustov Andrei | President | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 17, 2023 | Jan 18, 2023 | Longcor Jarrod | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 17, 2023 | Jan 18, 2023 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 17, 2023 | Jan 18, 2023 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 21, 2022 | Dec 15, 2022 | Lea Darrell Shane | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2022 | Lea Darrell Shane | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 24, 2022 | Aug 1, 2022 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2022 | Aug 1, 2022 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2022 | Aug 1, 2022 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2022 | Aug 1, 2022 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2022 | Aug 1, 2022 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 15, 2022 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 22, 2022 | Feb 24, 2022 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 24, 2022 | Kolean Chad J | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 25, 2022 | Jan 27, 2022 | Longcor Jarrod | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 25, 2022 | Jan 27, 2022 | Elefant Dov | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 25, 2022 | Jan 27, 2022 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 14, 2021 | Sep 14, 2021 | Swirsky Douglas J | Director | Buy | 91.3 | +25,000 | 100.00% | ✗ | $26K |
| Sep 3, 2021 | Sep 7, 2021 | DRISCOLL FREDERICK W | Director | Buy | 91.3 | +19,417 | 100.00% | ✗ | $20.2K |
| Jun 30, 2021 | Jul 2, 2021 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 30, 2021 | Jul 2, 2021 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 30, 2021 | Jul 2, 2021 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 30, 2021 | Jul 2, 2021 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 30, 2021 | Jul 2, 2021 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 2, 2021 | Chanan-Khan Asher | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 17, 2021 | Mar 19, 2021 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2021 | Mar 16, 2021 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2021 | Mar 5, 2021 | Elefant Dov | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2021 | Mar 5, 2021 | Longcor Jarrod | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2021 | Mar 5, 2021 | Friend John E. II | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2021 | Mar 5, 2021 | CARUSO JAMES V | CEO | Buy | 85.0 | +5,100 | 6.27% | ✗ | $8.7K |
| Dec 28, 2020 | Dec 28, 2020 | CARUSO JAMES V | CEO | Buy | 91.3 | +37,037 | 83.67% | ✗ | $50K |
| Dec 28, 2020 | Dec 28, 2020 | Longcor Jarrod | Chief Business Officer | Buy | 91.3 | +29,630 | 40.86% | ✗ | $40K |
| Dec 28, 2020 | Dec 28, 2020 | Elefant Dov | CFO | Buy | 90.0 | +7,407 | 170.35% | ✗ | $10K |
| Jul 1, 2020 | Jul 6, 2020 | Friend John E. II | VP, Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 6, 2020 | Friend John E. II | VP, Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 24, 2020 | Jun 25, 2020 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2020 | Jun 25, 2020 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2020 | Jun 25, 2020 | HILL STEPHEN A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2020 | Jun 25, 2020 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2020 | Jun 25, 2020 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2020 | Jun 8, 2020 | HILL STEPHEN A | Director | Buy | 91.3 | +18,000 | 100.00% | ✗ | $19.4K |
| Jun 5, 2020 | Jun 8, 2020 | Elefant Dov | CFO | Buy | 90.0 | +4,348 | 100.00% | ✗ | $5K |
| Jun 5, 2020 | Jun 8, 2020 | Longcor Jarrod | Chief Business Officer | Buy | 95.0 | +65,218 | 893.40% | ✗ | $74.7K |
| Jun 5, 2020 | Jun 8, 2020 | CARUSO JAMES V | CEO | Buy | 91.3 | +21,740 | 96.52% | ✗ | $24.9K |
| Feb 3, 2020 | Mar 5, 2020 | Elefant Dov | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 3, 2020 | Mar 5, 2020 | Longcor Jarrod | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 3, 2020 | Mar 5, 2020 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 3, 2020 | Feb 4, 2020 | Elefant Dov | CFO | Neutral | 90.0 | +10,000 | 100.00% | ✗ | - |
| Feb 3, 2020 | Feb 4, 2020 | Longcor Jarrod | Chief Business Officer | Neutral | 90.0 | +40,000 | 100.00% | ✗ | - |
| Feb 3, 2020 | Feb 4, 2020 | CARUSO JAMES V | CEO | Neutral | 90.0 | +100,000 | 100.00% | ✗ | - |
| Jan 6, 2020 | Jan 8, 2020 | Grachev Igor D | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 8, 2020 | Grachev Igor D | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 10, 2019 | Sep 11, 2019 | Elefant Dov | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 11, 2019 | Elefant Dov | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 13, 2019 | Jun 14, 2019 | HILL STEPHEN A | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2019 | Jun 14, 2019 | DRISCOLL FREDERICK W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2019 | Jun 14, 2019 | Loren Stefan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2019 | Jun 14, 2019 | Swirsky Douglas J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2019 | Jun 14, 2019 | NEIS JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 11, 2019 | Bernhardt Charles Thomas III | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 28, 2019 | Mar 1, 2019 | Longcor Jarrod | Chief Business Officer | Buy | 77.5 | +100 | 1.39% | ✗ | $200.3 |
| Jan 17, 2019 | Jan 18, 2019 | Longcor Jarrod | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 17, 2019 | Jan 18, 2019 | POSNER BRIAN M | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 17, 2019 | Jan 18, 2019 | CARUSO JAMES V | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 30, 2018 | Nov 30, 2018 | CARUSO JAMES V | CEO | Buy | 82.5 | +1,000 | 4.68% | ✗ | $2.3K |