2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Isaly Samuel D | Director | 5,379,349 | Jun 27, 2016 |
| Gould Terry P | Director | 3,275,616 | Jun 17, 2024 |
| Adams Street Partners Llc | 10% Owner | 3,275,616 | Aug 15, 2022 |
| Orbimed Advisors Llc | Director | 1,397,684 | Jul 1, 2025 |
| OrbiMed Capital GP V LLC | Director | 1,397,684 | Jul 1, 2025 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Jan 28, 2026 | Jan 30, 2026 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2025 | Dec 8, 2025 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2025 | Dec 8, 2025 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2025 | Dec 8, 2025 | Arcara Jeffrey | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2025 | Dec 8, 2025 | LEA LEIV | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 2, 2025 | Oct 6, 2025 | Moore David Scott | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 6, 2025 | Moore David Scott | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 27, 2025 | Jul 1, 2025 | ORBIMED ADVISORS LLC | Director | Sell | 17.5 | -1,176,332 | -14.10% | ✗ | $4.9M |
| Jun 27, 2025 | Jul 1, 2025 | Thompson Peter A. | Director | Sell | 17.5 | -1,176,332 | -14.10% | ✗ | $4.9M |
| Jun 12, 2025 | Jun 16, 2025 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2025 | Jun 6, 2025 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 7, 2025 | May 9, 2025 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 8, 2025 | Apr 9, 2025 | van den Broek Richard | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 9, 2025 | van den Broek Richard | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 20, 2024 | Dec 23, 2024 | Arcara Jeffrey | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 20, 2024 | Dec 23, 2024 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 20, 2024 | Dec 23, 2024 | LEA LEIV | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 20, 2024 | Dec 23, 2024 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 10, 2024 | May 14, 2024 | MILLER RICHARD A MD | CEO | Neutral | 27.5 | -302,016 | -14.61% | ✗ | - |
| May 6, 2024 | May 8, 2024 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 6, 2024 | May 8, 2024 | ORBIMED ADVISORS LLC | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 6, 2024 | May 7, 2024 | Jones William Benton | Officer | Buy | 91.3 | +20,000 | 14.95% | ✗ | $34.6K |
| May 6, 2024 | May 7, 2024 | MILLER RICHARD A MD | CEO | Buy | 97.5 | +577,634 | 38.76% | ✗ | $1M |
| Feb 28, 2024 | Mar 1, 2024 | Arcara Jeffrey | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 8, 2024 | Arcara Jeffrey | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 6, 2023 | Dec 8, 2023 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | LEA LEIV | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2023 | Dec 8, 2023 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2023 | May 16, 2023 | Grais Linda | Director | Buy | 91.3 | +10,000 | 100.00% | ✗ | $24.5K |
| Mar 31, 2023 | Apr 3, 2023 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 20, 2022 | Dec 20, 2022 | Jones William Benton | Officer | Buy | 91.3 | +20,000 | 17.58% | ✗ | $15.8K |
| Dec 13, 2022 | Dec 15, 2022 | LEA LEIV | CFO | Buy | 91.3 | +34,000 | 13.69% | ✗ | $25.6K |
| Dec 13, 2022 | Dec 15, 2022 | MILLER RICHARD A MD | CEO | Buy | 83.8 | +60,000 | 4.20% | ✗ | $44.8K |
| Sep 28, 2022 | Sep 28, 2022 | MILLER RICHARD A MD | CEO | Buy | 78.8 | +25,000 | 1.78% | ✗ | $19.1K |
| Sep 20, 2022 | Sep 20, 2022 | MILLER RICHARD A MD | CEO | Buy | 78.8 | +20,000 | 1.44% | ✗ | $16.3K |
| Aug 11, 2022 | Aug 15, 2022 | LEA LEIV | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 11, 2022 | Aug 15, 2022 | ADAMS STREET PARTNERS LLC | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2022 | Jun 28, 2022 | MILLER RICHARD A MD | CEO | Buy | 68.8 | +10,000 | 0.73% | ✗ | $10.1K |
| Jun 15, 2022 | Jun 17, 2022 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 2, 2022 | Jun 6, 2022 | MILLER RICHARD A MD | CEO | Buy | 60.0 | +5,890 | 0.43% | ✗ | $5.8K |
| Mar 31, 2022 | Apr 1, 2022 | MILLER RICHARD A MD | CEO | Buy | 78.8 | +15,000 | 1.11% | ✗ | $24.5K |
| Mar 16, 2022 | Mar 17, 2022 | LEA LEIV | CFO | Buy | 95.0 | +49,038 | 24.59% | ✗ | $77K |
| Mar 15, 2022 | Mar 17, 2022 | MILLER RICHARD A MD | CEO | Buy | 78.8 | +30,000 | 2.27% | ✗ | $44.6K |
| Sep 30, 2021 | Oct 1, 2021 | EcoR1 Capital, LLC | 10% Owner | Sell | 15.0 | -5,000,000 | -98.40% | ✗ | $25.1M |
| Sep 20, 2021 | Sep 22, 2021 | ORBIMED ADVISORS LLC | Director | Sell | 16.3 | -1,109,644 | -13.78% | ✗ | $6.8M |
| Sep 20, 2021 | Sep 22, 2021 | Thompson Peter A. | Director | Sell | 16.3 | -1,109,644 | -13.78% | ✗ | $6.8M |
| Sep 22, 2021 | EcoR1 Capital, LLC | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 9, 2021 | Sep 13, 2021 | MILLER RICHARD A MD | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | LEA LEIV | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Jones William Benton | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2021 | Sep 13, 2021 | ADAMS STREET PARTNERS LLC | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2021 | Aug 23, 2021 | MILLER RICHARD A MD | CEO | Buy | 68.8 | +10,000 | 0.76% | ✗ | $19.3K |
| Jun 15, 2021 | Jun 16, 2021 | Mitchell Edith P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Grais Linda | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | CLARK IAN T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Morrison Scott W | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Gould Terry P | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | ADAMS STREET PARTNERS LLC | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 4, 2021 | May 5, 2021 | MILLER RICHARD A MD | CEO | Buy | 87.5 | +35,714 | 2.79% | ✗ | $100K |
| Feb 17, 2021 | Feb 19, 2021 | ORBIMED ADVISORS LLC | Director | Buy | 100.0 | +1,285,714 | 19.00% | ✗ | $4.5M |