2025Q4
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| 21 April Fund, Ltd. | 10% Owner | 26,476,546 | Jun 24, 2019 |
| 21 April Fund, L.P. | 10% Owner | 26,476,546 | Jun 24, 2019 |
| First Eagle Value in Biotechnology Master Fund, Ltd. | 10% Owner | 26,476,546 | Jun 24, 2019 |
| Asen R Scott | 10% Owner | 2,666,612 | Aug 22, 2025 |
| Bleichroeder LP | 10% Owner | 2,637,965 | Mar 15, 2023 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Sep 11, 2025 | Sep 16, 2025 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | Robertson Judith J. | Director | Neutral | 47.5 | -41,113 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | BROWN JAMES E | CEO | Neutral | 47.5 | -553,335 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | Maderis Gail J | Director | Neutral | 47.5 | -25,500 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | Sussman Norman | Chief Medical Officer | Neutral | 47.5 | -46,425 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | Farfel Gail M | Director | Neutral | 47.5 | -15,500 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | GARCIA PETER S | Director | Neutral | 47.5 | -12,500 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | AZAB MOHAMMAD | Director | Neutral | 47.5 | -6,000 | -100.00% | ✗ | - |
| Sep 11, 2025 | Sep 12, 2025 | Papp Timothy M. | CFO | Neutral | 47.5 | -431,659 | -100.00% | ✗ | - |
| Sep 10, 2025 | Sep 11, 2025 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2025 | Sep 11, 2025 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 10, 2025 | Sep 11, 2025 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2025 | Sep 11, 2025 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2025 | Sep 11, 2025 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 8, 2025 | Sep 10, 2025 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 8, 2025 | Sep 9, 2025 | Papp Timothy M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 22, 2025 | Aug 26, 2025 | ASEN R SCOTT | 10% Owner | Buy | 56.3 | +5,917 | 0.16% | ✗ | $11.4K |
| Aug 20, 2025 | Aug 22, 2025 | ASEN R SCOTT | 10% Owner | Buy | 92.5 | +204,220 | 5.95% | ✗ | $386.7K |
| Aug 14, 2025 | ASEN R SCOTT | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jul 11, 2025 | Jul 15, 2025 | BROWN JAMES E | CEO | Neutral | 90.0 | +96,959 | 54.95% | ✗ | - |
| Jul 11, 2025 | Jul 15, 2025 | Sussman Norman | Chief Medical Officer | Neutral | 90.0 | +46,425 | 100.00% | ✗ | - |
| Jul 11, 2025 | Jul 15, 2025 | Papp Timothy M. | CFO | Neutral | 90.0 | +46,659 | 16.97% | ✗ | - |
| Oct 14, 2024 | Oct 16, 2024 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 14, 2024 | Oct 16, 2024 | Papp Timothy M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 14, 2024 | Oct 16, 2024 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | Blaschke Terrence F | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 25, 2024 | Sep 27, 2024 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 10, 2021 | Sep 11, 2024 | Sussman Norman | Chief Medical Officer | Sell | 27.5 | -9,000 | -100.00% | ✗ | $9.5K |
| Jun 12, 2023 | Aug 6, 2024 | BROWN JAMES E | CEO | Neutral | 27.5 | -56,000 | -23.29% | ✗ | - |
| Jul 26, 2024 | Jul 30, 2024 | Papp Timothy M. | CFO | Neutral | 90.0 | +275,000 | 100.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | Blaschke Terrence F | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2023 | Jun 23, 2023 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 13, 2023 | Mar 15, 2023 | Bleichroeder LP | 10% Owner | Neutral | 52.5 | -3,498 | -0.13% | ✗ | - |
| Feb 21, 2023 | Feb 23, 2023 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 21, 2023 | Feb 23, 2023 | Papp Timothy M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 21, 2023 | Feb 23, 2023 | Joice Judy R | Sr. VP Operations & Corp QA | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 21, 2023 | Feb 23, 2023 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 18, 2022 | Aug 22, 2022 | Robertson Judith J. | Director | Buy | 95.0 | +80,942 | 29.41% | ✗ | $68.8K |
| Aug 17, 2022 | Aug 19, 2022 | Robertson Judith J. | Director | Buy | 82.5 | +10,189 | 3.84% | ✗ | $8.6K |
| Aug 12, 2022 | Aug 12, 2022 | Maderis Gail J | Director | Buy | 91.3 | +25,204 | 14.42% | ✗ | $18K |
| Aug 9, 2022 | Aug 11, 2022 | Maderis Gail J | Director | Buy | 95.0 | +174,796 | 100.00% | ✗ | $117.1K |
| Jul 1, 2022 | Jul 5, 2022 | Papp Timothy M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 5, 2022 | Papp Timothy M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 15, 2022 | Jun 17, 2022 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | HOFFMANN DAVE | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Blaschke Terrence F | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 26, 2022 | May 27, 2022 | Robertson Judith J. | Director | Buy | 91.3 | +65,000 | 32.50% | ✗ | $25.6K |
| May 24, 2022 | May 25, 2022 | AZAB MOHAMMAD | Director | Buy | 91.3 | +30,000 | 100.00% | ✗ | $11.6K |
| May 16, 2022 | May 18, 2022 | Farfel Gail M | Director | Buy | 91.3 | +55,211 | 123.27% | ✗ | $22K |
| May 16, 2022 | May 18, 2022 | AZAB MOHAMMAD | Director | Buy | 91.3 | +30,000 | 100.00% | ✗ | $12.2K |
| May 11, 2022 | May 13, 2022 | Farfel Gail M | Director | Buy | 90.0 | +20,700 | 85.93% | ✗ | $8.3K |
| May 10, 2022 | May 12, 2022 | Farfel Gail M | Director | Buy | 90.0 | +2,339 | 10.75% | ✗ | $949.6 |
| May 9, 2022 | May 10, 2022 | Farfel Gail M | Director | Buy | 90.0 | +21,750 | 100.00% | ✗ | $8.6K |
| Mar 25, 2022 | JIAN LI | InterimPrincipalAccountingOfcr | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 14, 2022 | Mar 16, 2022 | Robertson Judith J. | Director | Buy | 95.0 | +200,000 | 100.00% | ✗ | $118K |
| Jan 6, 2022 | Jan 10, 2022 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2022 | Jan 10, 2022 | Joice Judy R | Sr. VP Operations & Corp QA | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2022 | Jan 10, 2022 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2022 | Jan 10, 2022 | Arenberg Michael | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 13, 2021 | Dec 14, 2021 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 14, 2021 | GARCIA PETER S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 7, 2021 | Dec 9, 2021 | BENITO SIMON X | Director | Buy | 91.3 | +20,000 | 23.53% | ✗ | $20.4K |
| Jun 15, 2021 | Jun 16, 2021 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | HOFFMANN DAVE | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | Blaschke Terrence F | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | BENITO SIMON X | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2021 | Jun 16, 2021 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 14, 2021 | May 17, 2021 | Joice Judy R | Sr. VP Operations & Corp QA | Sell | 22.5 | -60,137 | -63.32% | ✗ | $103.7K |
| Jan 15, 2021 | Jan 19, 2021 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 15, 2021 | Jan 19, 2021 | Joice Judy R | Sr. VP Operations & Corp QA | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 15, 2021 | Jan 19, 2021 | BROWN JAMES E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 15, 2021 | Jan 19, 2021 | Arenberg Michael | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 4, 2021 | Jan 5, 2021 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 5, 2021 | AZAB MOHAMMAD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 4, 2021 | Jan 5, 2021 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 5, 2021 | Maderis Gail J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 2, 2020 | Nov 4, 2020 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 4, 2020 | Sussman Norman | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 1, 2020 | Sep 2, 2020 | Bleichroeder LP | 10% Owner | Sell | 30.0 | -250,000 | -0.94% | ✗ | $420K |
| Jun 17, 2020 | Jun 19, 2020 | Robertson Judith J. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | HOFFMANN DAVE | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | Blaschke Terrence F | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | SAXE JON S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | Neukermans Armand | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | BENITO SIMON X | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2020 | Jun 18, 2020 | Farfel Gail M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |