Karyopharm Therapeutics Inc. (KPTI)

Latest Insider Confidence Score

2026Q1

50.6
Bullish

Company insider confidence (by quarter)

2013Q4 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Hadjimichael Amalia 10% Owner 9,132,700 Dec 1, 2014
Chione Ltd 10% Owner 6,000,000 Mar 4, 2019
Czernik Marcin 10% Owner 6,000,000 Mar 4, 2019
Hadjimichael Andreas 10% Owner 6,000,000 Mar 4, 2019
Hadjimichael George 10% Owner 6,000,000 Mar 4, 2019

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Mar 2, 2026 Mar 3, 2026 Abate Kristin Chief Accounting Officer Sell 47.5 -559 -2.47% ✗ $5.3K
Mar 2, 2026 Mar 3, 2026 Mano Michael EVP, CLO&Secretary Sell 46.3 -3,526 -3.62% ✗ $33.2K
Mar 2, 2026 Mar 3, 2026 Cheng Sohanya Roshan EVP & Chief Commercial Officer Sell 46.3 -4,604 -4.11% ✗ $43.3K
Mar 2, 2026 Mar 3, 2026 Rangwala Reshma EVP & Chief Medical Officer Sell 46.3 -5,066 -8.20% ✗ $47.7K
Mar 2, 2026 Mar 3, 2026 Paulson Richard A. CEO Sell 42.5 -12,361 -4.42% ✗ $116.3K
Mar 2, 2026 Mar 3, 2026 Poulton Stuart EVP, Chief Development Officer Sell 46.3 -5,101 -5.13% ✗ $48K
Feb 17, 2026 Feb 19, 2026 Poulton Stuart EVP, Chief Development Officer Sell 52.5 -378 -0.38% ✗ $3.3K
Feb 5, 2026 Feb 9, 2026 Paulson Richard A. CEO Neutral 90.0 +81,060 40.87% ✗ -
Feb 3, 2026 Feb 4, 2026 Macomber Lori CFO Sell 46.3 -1,626 -1.87% ✗ $10.2K
Jan 31, 2026 Feb 3, 2026 Cheng Sohanya Roshan EVP & Chief Commercial Officer Neutral 90.0 +32,415 40.77% ✗ -
Jan 31, 2026 Feb 3, 2026 Rangwala Reshma EVP & Chief Medical Officer Neutral 90.0 +32,415 110.29% ✗ -
Jan 31, 2026 Feb 3, 2026 Macomber Lori CFO Neutral 90.0 +32,415 59.68% ✗ -
Jan 31, 2026 Feb 3, 2026 Mano Michael EVP, CLO&Secretary Neutral 90.0 +32,415 49.81% ✗ -
Jan 31, 2026 Feb 3, 2026 Poulton Stuart EVP, Chief Development Officer Neutral 90.0 +32,415 48.10% ✗ -
Jan 27, 2026 Jan 29, 2026 Abate Kristin Chief Accounting Officer Sell 55.0 +42 0.19% ✗ $351.5
Jan 21, 2026 Jan 22, 2026 Abate Kristin Chief Accounting Officer Sell 47.5 -265 -1.16% ✗ $1.6K
Oct 15, 2025 Oct 16, 2025 Abate Kristin Chief Accounting Officer Neutral 90.0 +12,799 127.40% ✗ -
Oct 15, 2025 Oct 16, 2025 Poulton Stuart EVP, Chief Development Officer Neutral 90.0 +39,682 143.20% ✗ -
Oct 15, 2025 Oct 16, 2025 Mano Michael SVP, General Counsel&Secretary Neutral 90.0 +43,650 203.73% ✗ -
Oct 15, 2025 Oct 16, 2025 Paulson Richard A. CEO Neutral 90.0 +114,285 135.98% ✗ -
Oct 15, 2025 Oct 16, 2025 Cheng Sohanya Roshan EVP & Chief Commercial Officer Neutral 90.0 +43,650 121.74% ✗ -
Oct 15, 2025 Oct 16, 2025 Macomber Lori CFO Neutral 90.0 +43,650 409.24% ✗ -
Oct 1, 2025 Oct 3, 2025 Abate Kristin Chief Accounting Officer Sell 47.5 -362 -3.48% ✗ $2.3K
Sep 12, 2025 Sep 16, 2025 Paulson Richard A. CEO Sell 77.5 +1,543 1.87% ✗ $8.1K
Sep 12, 2025 Sep 16, 2025 Mano Michael SVP, General Counsel&Secretary Sell 77.5 +378 1.80% ✗ $1.5K
Sep 12, 2025 Sep 16, 2025 Poulton Stuart EVP, Chief Development Officer Sell 77.5 +487 1.79% ✗ $2.6K
Sep 12, 2025 Sep 16, 2025 Rangwala Reshma EVP & Chief Medical Officer Sell 77.5 +537 1.86% ✗ $2.6K
Sep 12, 2025 Sep 16, 2025 Cheng Sohanya Roshan EVP & Chief Commercial Officer Sell 77.5 +620 1.76% ✗ $2.1K
Sep 12, 2025 Sep 16, 2025 Abate Kristin Chief Accounting Officer Sell 60.0 +23 0.22% ✗ $147.9
Sep 3, 2025 Sep 4, 2025 Abate Kristin Chief Accounting Officer Sell 52.5 -12 -0.13% ✗ $81.4
Jul 29, 2025 Jul 30, 2025 Poulton Stuart EVP, Chief Development Officer Sell 50.0 -191 -0.70% ✗ $834.7
Jul 22, 2025 Jul 23, 2025 Abate Kristin Chief Accounting Officer Sell 47.5 -238 -2.45% ✗ $952
May 28, 2025 May 29, 2025 Su Zhen Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 PAKIANATHAN DEEPIKA Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 Oliger Christy J. Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 Mirza Mansoor Raza Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 Greene Barry E Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 Schor Chen Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 29, 2025 BOHLIN GAREN G Director Neutral 52.5 - 0.00% ✗ -
May 6, 2025 May 7, 2025 Paulson Richard A. CEO Sell 52.5 -236 -0.29% ✗ $1.7K
Apr 23, 2025 Apr 24, 2025 Rangwala Reshma EVP & Chief Medical Officer Sell 47.5 -419 -1.43% ✗ $2.6K
Apr 4, 2025 Apr 7, 2025 Paulson Richard A. CEO Sell 52.5 -245 -0.30% ✗ $916.3
Mar 4, 2025 Mar 6, 2025 Cheng Sohanya Roshan EVP & Chief Commercial Officer Sell 46.3 -3,445 -9.12% ✗ $21.7K
Mar 4, 2025 Mar 6, 2025 Paulson Richard A. CEO Sell 42.5 -11,694 -12.35% ✗ $73.6K
Mar 4, 2025 Mar 6, 2025 Rangwala Reshma EVP & Chief Medical Officer Sell 46.3 -3,587 -10.92% ✗ $22.6K
Mar 4, 2025 Mar 6, 2025 Poulton Stuart EVP, Chief Development Officer Sell 46.3 -3,548 -11.46% ✗ $22.3K
Mar 4, 2025 Mar 6, 2025 Abate Kristin Chief Accounting Officer Sell 47.5 -571 -5.55% ✗ $3.6K
Mar 4, 2025 Mar 6, 2025 Mano Michael SVP, General Counsel&Secretary Sell 46.3 -2,793 -11.72% ✗ $17.6K
Feb 28, 2025 Mar 4, 2025 Cheng Sohanya Roshan EVP & Chief Commercial Officer Neutral 90.0 +9,999 36.02% ✗ -
Feb 28, 2025 Mar 4, 2025 Rangwala Reshma EVP & Chief Medical Officer Neutral 90.0 +9,999 43.74% ✗ -
Feb 28, 2025 Mar 4, 2025 Poulton Stuart EVP, Chief Development Officer Neutral 90.0 +9,583 44.82% ✗ -
Feb 28, 2025 Mar 4, 2025 Abate Kristin Chief Accounting Officer Neutral 85.0 +933 9.98% ✗ -
Feb 28, 2025 Mar 4, 2025 Paulson Richard A. CEO Neutral 90.0 +20,000 26.78% ✗ -
Feb 28, 2025 Mar 4, 2025 Mano Michael SVP, General Counsel&Secretary Neutral 90.0 +5,583 30.58% ✗ -
Feb 18, 2025 Feb 19, 2025 Poulton Stuart EVP, Chief Development Officer Sell 47.5 -5,914 -1.81% ✗ $3.7K
Feb 4, 2025 Feb 5, 2025 Paulson Richard A. CEO Sell 52.5 -4,099 -0.36% ✗ $2.7K
Jan 31, 2025 Feb 3, 2025 Macomber Lori CFO Neutral 90.0 +160,000 100.00% ✗ -
Jan 6, 2025 Jan 7, 2025 Paulson Richard A. CEO Sell 52.5 -4,055 -0.36% ✗ $3.2K
Jan 6, 2025 Macomber Lori CFO Neutral 52.5 - 0.00% ✗ -
Dec 4, 2024 Dec 5, 2024 Paulson Richard A. CEO Sell 52.5 -3,620 -0.32% ✗ $2.9K
Nov 22, 2024 Abate Kristin Chief Accounting Officer Neutral 52.5 - 0.00% ✗ -
Nov 5, 2024 Nov 6, 2024 Paulson Richard A. CEO Sell 52.5 -3,675 -0.32% ✗ $3.3K
Oct 4, 2024 Oct 7, 2024 Paulson Richard A. CEO Sell 52.5 -3,607 -0.32% ✗ $3.2K
Sep 4, 2024 Sep 5, 2024 Mano Michael SVP, General Counsel&Secretary Sell 47.5 -3,971 -1.43% ✗ $2.9K
Sep 4, 2024 Sep 5, 2024 Paulson Richard A. CEO Sell 52.5 -3,667 -0.32% ✗ $2.6K
Sep 4, 2024 Sep 5, 2024 Mason Michael CFO Sell 47.5 -7,050 -1.77% ✗ $5.1K
Sep 4, 2024 Sep 5, 2024 Cheng Sohanya Roshan EVP & Chief Commercial Officer Sell 47.5 -5,356 -1.31% ✗ $3.9K
Aug 6, 2024 Aug 8, 2024 Paulson Richard A. CEO Sell 52.5 -3,608 -0.31% ✗ $3.4K
Jul 30, 2024 Jul 31, 2024 Poulton Stuart EVP, Chief Development Officer Sell 50.0 -2,883 -0.87% ✗ $3.1K
Jul 5, 2024 Jul 9, 2024 Paulson Richard A. CEO Sell 52.5 -3,616 -0.31% ✗ $3.1K
Jun 5, 2024 Jun 7, 2024 PAKIANATHAN DEEPIKA Director Sell 20.0 -818,044 -58.45% ✗ $785K
Jun 4, 2024 Jun 6, 2024 Mason Michael CFO Sell 52.5 -652 -0.16% ✗ $645.5
Jun 4, 2024 Jun 6, 2024 Paulson Richard A. CEO Sell 52.5 -3,592 -0.31% ✗ $3.6K
May 31, 2024 Jun 4, 2024 PAKIANATHAN DEEPIKA Director Sell 20.0 -906,178 -20.58% ✗ $880.7K
May 29, 2024 May 30, 2024 Su Zhen Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 Schor Chen Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 PAKIANATHAN DEEPIKA Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 Mirza Mansoor Raza Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 Oliger Christy J. Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 Greene Barry E Director Neutral 52.5 - 0.00% ✗ -
May 29, 2024 May 30, 2024 BOHLIN GAREN G Director Neutral 52.5 - 0.00% ✗ -
May 6, 2024 May 7, 2024 Paulson Richard A. CEO Sell 52.5 -3,576 -0.31% ✗ $4K
Apr 22, 2024 Apr 23, 2024 Rangwala Reshma EVP & Chief Medical Officer Sell 47.5 -6,789 -1.94% ✗ $7.9K
Apr 4, 2024 Apr 5, 2024 Paulson Richard A. CEO Sell 52.5 -3,563 -0.31% ✗ $4.6K
Mar 5, 2024 Mar 6, 2024 Paulson Richard A. CEO Sell 52.5 -3,573 -0.31% ✗ $4.6K
Feb 29, 2024 Mar 4, 2024 Rangwala Reshma EVP & Chief Medical Officer Sell 46.3 -21,636 -5.83% ✗ $25.5K
Feb 29, 2024 Mar 4, 2024 Poulton Stuart EVP, Chief Development Officer Sell 46.3 -22,466 -6.38% ✗ $26.5K
Feb 29, 2024 Mar 4, 2024 Mason Michael CFO Sell 46.3 -33,849 -7.82% ✗ $39.8K
Feb 29, 2024 Mar 4, 2024 Mano Michael SVP, General Counsel&Secretary Sell 46.3 -20,549 -6.89% ✗ $24.1K
Feb 29, 2024 Mar 4, 2024 Cheng Sohanya Roshan EVP & Chief Commercial Officer Sell 46.3 -26,949 -6.41% ✗ $31.7K
Feb 29, 2024 Mar 4, 2024 Paulson Richard A. CEO Sell 42.5 -99,844 -7.90% ✗ $117.4K
Feb 28, 2024 Feb 29, 2024 Rangwala Reshma EVP & Chief Medical Officer Neutral 90.0 +198,959 115.41% ✗ -
Feb 28, 2024 Feb 29, 2024 Poulton Stuart EVP, Chief Development Officer Neutral 90.0 +188,205 114.92% ✗ -
Feb 27, 2024 Feb 29, 2024 Mason Michael CFO Sell 90.0 +185,660 75.18% ✗ $3.4K
Feb 28, 2024 Feb 29, 2024 Mano Michael SVP, General Counsel&Secretary Neutral 90.0 +147,000 97.09% ✗ -
Feb 28, 2024 Feb 29, 2024 Cheng Sohanya Roshan EVP & Chief Commercial Officer Neutral 90.0 +198,959 89.82% ✗ -
Feb 28, 2024 Feb 29, 2024 Paulson Richard A. CEO Neutral 90.0 +442,800 53.90% ✗ -
Feb 15, 2024 Feb 20, 2024 Poulton Stuart EVP, Chief Development Officer Sell 47.5 -5,847 -3.45% ✗ $7.8K
Feb 6, 2024 Feb 8, 2024 Mason Michael CFO Sell 47.5 -4,205 -1.67% ✗ $6.7K
Feb 6, 2024 Feb 8, 2024 Paulson Richard A. CEO Sell 52.5 -4,012 -0.49% ✗ $6.4K