Lyra Therapeutics, Inc. (LYRA)

Latest Insider Confidence Score

2026Q1

48.3
Bearish

Company insider confidence (by quarter)

2020Q2 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Damore Richard A 10% Owner 601,806 Jun 2, 2023
Nbvm Gp, Llc 10% Owner 601,806 Jun 2, 2023
North Bridge Venture Partners VI L P 10% Owner 601,806 Jun 2, 2023
North Bridge Venture Management VI, L.P. 10% Owner 601,806 Jun 2, 2023
North Bridge Venture Partners V A Lp 10% Owner 601,806 Jun 2, 2023

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Jan 6, 2026 Jan 8, 2026 Cavalier Jason CFO Sell 53.8 -769 -0.15% ✓ $2.6K
Jan 6, 2026 Jan 8, 2026 Palasis Maria CEO Sell 53.8 -1,702 -0.15% ✓ $5.7K
Nov 11, 2025 Nov 13, 2025 PERCEPTIVE ADVISORS LLC 10% Owner Sell 22.5 -45,875 -8.58% ✗ $182.5K
Nov 6, 2025 Nov 10, 2025 PERCEPTIVE ADVISORS LLC 10% Owner Sell 20.0 -70,390 -10.33% ✗ $344.2K
Oct 8, 2025 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Oct 1, 2025 Oct 3, 2025 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Jul 10, 2025 Jul 14, 2025 Palasis Maria CEO Sell 53.8 -1,565 -0.14% ✓ $13.9K
Jul 10, 2025 Jul 14, 2025 Cavalier Jason CFO Sell 55.0 -684 -0.13% ✓ $6.1K
May 14, 2025 May 16, 2025 MERRIFIELD C ANN Director Neutral 52.5 - 0.00% ✗ -
May 14, 2025 May 16, 2025 TOBIN JAMES R Director Neutral 52.5 - 0.00% ✗ -
May 14, 2025 May 16, 2025 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
May 14, 2025 May 16, 2025 Smith W Bradford Director Neutral 52.5 - 0.00% ✗ -
Jan 8, 2025 Jan 10, 2025 Palasis Maria CEO Neutral 90.0 +800,000 266.67% ✗ -
Jan 8, 2025 Jan 10, 2025 Cavalier Jason CFO Neutral 90.0 +420,000 420.00% ✗ -
Dec 9, 2024 Dec 11, 2024 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Dec 9, 2024 Dec 11, 2024 Waksal Harlan Chair Neutral 52.5 - 0.00% ✗ -
Oct 16, 2024 Oct 18, 2024 Palasis Maria CEO Neutral 90.0 +300,000 100.00% ✗ -
Oct 16, 2024 Oct 18, 2024 Cavalier Jason CFO Neutral 90.0 +100,000 100.00% ✗ -
Jun 13, 2024 Jun 14, 2024 ALTMAN MICHAEL SETH Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2024 Jun 14, 2024 Poukalov Konstantin Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2024 Jun 14, 2024 TOBIN JAMES R Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2024 Jun 14, 2024 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2024 Jun 14, 2024 Smith W Bradford Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2024 Jun 14, 2024 MERRIFIELD C ANN Director Neutral 52.5 - 0.00% ✗ -
Mar 18, 2024 Mar 20, 2024 Waksal Harlan Chair Neutral 90.0 +275,000 104.98% ✗ -
Mar 18, 2024 Mar 20, 2024 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Jan 30, 2024 Feb 1, 2024 Bishop John E Chief Technology Officer Neutral 52.5 - 0.00% ✗ -
Jan 30, 2024 Feb 1, 2024 Nieman Richard Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 30, 2024 Feb 1, 2024 Cavalier Jason CFO Neutral 52.5 - 0.00% ✗ -
Nov 10, 2023 Nov 13, 2023 Waksal Harlan Chair Buy 95.0 +25,000 10.55% ✗ $74.1K
Jun 15, 2023 Jul 12, 2023 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 TOBIN JAMES R Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 Smith W Bradford Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 Poukalov Konstantin Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 ALTMAN MICHAEL SETH Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 MERRIFIELD C ANN Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 ANDERSON EDWARD T Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
Jun 15, 2023 Jun 26, 2023 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
May 31, 2023 Jun 2, 2023 NBVM GP, LLC 10% Owner Buy 100.0 +1,805,416 44.22% ✗ $4.4M
May 31, 2023 Jun 2, 2023 ANDERSON EDWARD T Director Buy 100.0 +1,805,416 42.97% ✗ $4.4M
May 31, 2023 Jun 2, 2023 PERCEPTIVE ADVISORS LLC Director Buy 100.0 +3,610,832 45.95% ✗ $9M
Feb 27, 2023 Feb 28, 2023 Bishop John E Chief Technology Officer Neutral 52.5 - 0.00% ✗ -
Feb 28, 2023 Bishop John E Chief Technology Officer Neutral 52.5 - 0.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Richard Robert E. SVP, Technical Operations Neutral 90.0 +30,000 100.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Waksal Harlan Chair Neutral 52.5 - 0.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Noyes Corinne Officer Neutral 90.0 +36,667 100.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Cavalier Jason CFO Neutral 52.5 - 0.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Jan 31, 2023 Feb 2, 2023 Nieman Richard Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jul 11, 2022 Jul 12, 2022 Nieman Richard Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jul 12, 2022 Nieman Richard Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 MERRIFIELD C ANN Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 ALTMAN MICHAEL SETH Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 Smith W Bradford Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 Poukalov Konstantin Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 Waksal Harlan Chair Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 ANDERSON EDWARD T Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2022 Jun 21, 2022 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
Jun 10, 2022 Jun 13, 2022 MERRIFIELD C ANN Director Buy 91.3 +4,000 54.59% ✗ $20.2K
May 13, 2022 May 17, 2022 MERRIFIELD C ANN Director Buy 91.3 +3,828 109.37% ✗ $18.5K
Apr 12, 2022 Apr 14, 2022 PERCEPTIVE ADVISORS LLC Director Buy 100.0 +5,924,170 306.30% ✗ $25M
Apr 12, 2022 Apr 14, 2022 NBVM GP, LLC 10% Owner Buy 100.0 +2,369,667 138.31% ✗ $10M
Apr 12, 2022 Apr 14, 2022 ANDERSON EDWARD T Director Buy 100.0 +2,488,150 145.22% ✗ $10.5M
Apr 12, 2022 Apr 13, 2022 Waksal Harlan Chair Buy 97.5 +236,966 100.00% ✗ $1000K
Mar 4, 2022 Mar 8, 2022 TOBIN JAMES R Director Neutral 52.5 - 0.00% ✗ -
Mar 8, 2022 TOBIN JAMES R Director Neutral 52.5 - 0.00% ✗ -
Feb 16, 2022 Feb 18, 2022 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Feb 16, 2022 Feb 18, 2022 Waksal Harlan Chair Neutral 52.5 - 0.00% ✗ -
Feb 18, 2022 Waksal Harlan Chair Neutral 52.5 - 0.00% ✗ -
Feb 12, 2022 Feb 15, 2022 Noyes Corinne Officer Neutral 52.5 - 0.00% ✗ -
Feb 12, 2022 Feb 15, 2022 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Feb 12, 2022 Feb 15, 2022 Nelson Pamela E. SVP, Regulatory Affairs Neutral 52.5 - 0.00% ✗ -
Feb 12, 2022 Feb 15, 2022 Cavalier Jason CFO Neutral 52.5 - 0.00% ✗ -
Feb 12, 2022 Feb 15, 2022 Richard Robert E. SVP, Technical Operations Neutral 52.5 - 0.00% ✗ -
Sep 13, 2021 Sep 15, 2021 Cavalier Jason CFO Neutral 52.5 - 0.00% ✗ -
Sep 15, 2021 Cavalier Jason CFO Neutral 52.5 - 0.00% ✗ -
Jun 17, 2021 Jun 22, 2021 MERRIFIELD C ANN Director Buy 91.3 +3,500 100.00% ✗ $31.4K
May 26, 2021 May 28, 2021 ALTMAN MICHAEL SETH Director Neutral 52.5 - 0.00% ✗ -
May 26, 2021 May 28, 2021 Poukalov Konstantin Director Neutral 52.5 - 0.00% ✗ -
May 26, 2021 May 28, 2021 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
May 26, 2021 May 28, 2021 MERRIFIELD C ANN Director Neutral 52.5 - 0.00% ✗ -
May 26, 2021 May 28, 2021 Smith W Bradford Director Neutral 52.5 - 0.00% ✗ -
May 26, 2021 May 28, 2021 ANDERSON EDWARD T Director Neutral 52.5 - 0.00% ✗ -
Feb 8, 2021 Feb 10, 2021 Elsey R Don CFO Neutral 52.5 - 0.00% ✗ -
Feb 8, 2021 Feb 10, 2021 Palasis Maria CEO Neutral 52.5 - 0.00% ✗ -
Feb 8, 2021 Feb 10, 2021 Noyes Corinne Officer Neutral 52.5 - 0.00% ✗ -
Feb 8, 2021 Feb 10, 2021 Nelson Pamela E. Senior VP, Regulatory Affairs Neutral 52.5 - 0.00% ✗ -
Feb 8, 2021 Feb 10, 2021 Richard Robert E. SVP of R&D Neutral 52.5 - 0.00% ✗ -
Dec 16, 2020 Dec 17, 2020 snyderman nancy lynn MD Director Buy 90.0 +1,025 100.00% ✗ $10K
Oct 27, 2020 Oct 29, 2020 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
Oct 29, 2020 snyderman nancy lynn MD Director Neutral 52.5 - 0.00% ✗ -
Aug 3, 2020 Aug 5, 2020 Nelson Pamela E. Senior VP, Regulatory Affairs Neutral 52.5 - 0.00% ✗ -
Aug 5, 2020 Nelson Pamela E. Senior VP, Regulatory Affairs Neutral 52.5 - 0.00% ✗ -
Jun 24, 2020 Jun 26, 2020 Richard Robert E. SVP of R&D Neutral 52.5 - 0.00% ✗ -
Jun 26, 2020 Richard Robert E. SVP of R&D Neutral 52.5 - 0.00% ✗ -
May 5, 2020 May 29, 2020 PERCEPTIVE ADVISORS LLC Director Buy 100.0 +625,000 47.74% ✗ $10M
May 5, 2020 May 15, 2020 Soleus Private Equity GP I, LLC 10% Owner Buy 100.0 +138,091 29.11% ✗ $2.2M
May 15, 2020 Soleus Private Equity GP I, LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
May 5, 2020 May 6, 2020 PERCEPTIVE ADVISORS LLC Director Sell 17.5 -259,346 -9.08% ✗ $4.1M