2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Bvf Partners L P/Il | Director | 19,710,680 | Jun 9, 2025 |
| Biotechnology Value Fund L P | Director | 19,710,680 | Jun 9, 2025 |
| Bvf I Gp Llc | Director | 19,710,680 | Jun 9, 2025 |
| Biotechnology Value Fund II Lp | Director | 19,710,680 | Jun 9, 2025 |
| Bvf II Gp Llc | Director | 19,710,680 | Jun 9, 2025 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Jan 7, 2026 | Jan 9, 2026 | Bodenstedt Matthias | CFO | Neutral | 90.0 | +354,296 | 38.43% | ✗ | - |
| Jan 7, 2026 | Jan 9, 2026 | Santos da Silva Jorge | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 7, 2026 | Jan 9, 2026 | Reich Kristian | Chief Scientific Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 19, 2025 | Dec 22, 2025 | Bodenstedt Matthias | CFO | Neutral | 27.5 | -294,473 | -100.00% | ✗ | - |
| Dec 19, 2025 | Dec 22, 2025 | Reich Kristian | Chief Scientific Officer | Neutral | 27.5 | -35,389 | -1.18% | ✗ | - |
| Dec 19, 2025 | Dec 22, 2025 | Santos da Silva Jorge | CEO | Neutral | 27.5 | -196,316 | -100.00% | ✗ | - |
| Dec 8, 2025 | Dec 10, 2025 | Santos da Silva Jorge | CEO | Sell | 17.5 | -200,000 | -6.50% | ✗ | $3M |
| Dec 8, 2025 | Dec 10, 2025 | Reich Kristian | Chief Scientific Officer | Sell | 17.5 | -202,908 | -6.39% | ✗ | $3M |
| Oct 8, 2025 | Oct 9, 2025 | Bodenstedt Matthias | CFO | Buy | 82.5 | +10,870 | 1.76% | ✗ | $98.8K |
| Sep 29, 2025 | Oct 1, 2025 | Chen Bihua | Other | Sell | 15.0 | -6,499,978 | -76.52% | ✗ | $46.9M |
| Sep 2, 2025 | Sep 4, 2025 | Reich Kristian | Chief Scientific Officer | Neutral | 27.5 | -48,978 | -1.60% | ✗ | - |
| Jul 3, 2025 | Jul 7, 2025 | Moukheibir Catherine | Director | Sell | 17.5 | -23,500 | -100.00% | ✗ | $1.1M |
| Jun 5, 2025 | Jun 9, 2025 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Sturge Simon | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Loy Spike | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Xavier Ramnik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Moukheibir Catherine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Phillips Andrew John | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 27, 2025 | Mar 3, 2025 | Santos da Silva Jorge | CEO | Neutral | 82.5 | +95,763 | 3.21% | ✗ | - |
| Feb 27, 2025 | Mar 3, 2025 | Reich Kristian | Chief Scientific Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 27, 2025 | Mar 3, 2025 | Bodenstedt Matthias | CFO | Neutral | 90.0 | +95,763 | 18.38% | ✗ | - |
| Jan 20, 2025 | Jan 22, 2025 | Reich Kristian | Chief Scientific Officer | Neutral | 27.5 | -111,949 | -3.59% | ✗ | - |
| Oct 4, 2024 | Oct 8, 2024 | BVF PARTNERS L P/IL | Director | Sell | 15.0 | -2,000,000 | -9.22% | ✗ | $100M |
| Oct 4, 2024 | Oct 8, 2024 | Sturge Simon | Director | Sell | 16.3 | -171,000 | -49.86% | ✗ | $9.2M |
| Jun 6, 2024 | Jun 10, 2024 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Moukheibir Catherine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Phillips Andrew John | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Xavier Ramnik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Sturge Simon | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Loy Spike | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 27, 2024 | Feb 29, 2024 | Santos da Silva Jorge | CEO | Sell | 31.3 | -123,615 | -3.98% | ✓ | $6.8M |
| Feb 27, 2024 | Feb 29, 2024 | Reich Kristian | Chief Scientific Officer | Sell | 31.3 | -118,922 | -3.85% | ✓ | $6.5M |
| Feb 21, 2024 | Feb 23, 2024 | Santos da Silva Jorge | CEO | Sell | 53.8 | -1,125 | -0.04% | ✓ | $62.2K |
| Feb 20, 2024 | Feb 22, 2024 | Reich Kristian | Chief Scientific Officer | Sell | 42.5 | -21,078 | -0.68% | ✓ | $1.2M |
| Feb 15, 2024 | Feb 20, 2024 | Santos da Silva Jorge | CEO | Sell | 40.0 | -60,000 | -1.89% | ✓ | $3.6M |
| Feb 14, 2024 | Feb 16, 2024 | Reich Kristian | Chief Scientific Officer | Sell | 40.0 | -60,000 | -1.89% | ✓ | $3.7M |
| Dec 19, 2023 | Dec 21, 2023 | Bodenstedt Matthias | CFO | Sell | 13.8 | -100,000 | -16.11% | ✓ | $5.9M |
| Oct 5, 2023 | Oct 10, 2023 | Chen Bihua | 10% Owner | Buy | 77.5 | +58,839 | 0.70% | ✗ | $3.5M |
| Oct 2, 2023 | Oct 4, 2023 | Chen Bihua | 10% Owner | Buy | 95.0 | +293,212 | 3.60% | ✗ | $16.8M |
| Oct 1, 2023 | Oct 3, 2023 | Sturge Simon | Director | Neutral | 27.5 | -342,980 | -100.00% | ✗ | - |
| Oct 1, 2023 | Oct 3, 2023 | Bodenstedt Matthias | CFO | Neutral | 27.5 | -62,972 | -17.62% | ✗ | - |
| Oct 1, 2023 | Oct 3, 2023 | Santos da Silva Jorge | CEO | Neutral | 27.5 | -3,167,554 | -93.58% | ✗ | - |
| Oct 1, 2023 | Oct 3, 2023 | Reich Kristian | Chief Scientific Officer | Neutral | 27.5 | -2,569,458 | -92.90% | ✗ | - |
| Jun 30, 2023 | Jul 5, 2023 | Chen Bihua | 10% Owner | Buy | 100.0 | +800,000 | 19.38% | ✗ | $40M |
| Jun 26, 2023 | Jun 28, 2023 | Chen Bihua | 10% Owner | Buy | 100.0 | +450,000 | 12.24% | ✗ | $20.5M |
| Jun 8, 2023 | Jun 12, 2023 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2023 | Jun 12, 2023 | Sturge Simon | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2023 | Jun 12, 2023 | Xavier Ramnik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2023 | Jun 12, 2023 | Loy Spike | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2023 | Jun 12, 2023 | Moukheibir Catherine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2023 | Jun 12, 2023 | Phillips Andrew John | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 5, 2023 | Apr 7, 2023 | Bodenstedt Matthias | CFO | Neutral | 27.5 | -557,931 | -60.95% | ✗ | - |
| Apr 5, 2023 | Apr 7, 2023 | Reich Kristian | Chief Scientific Officer | Neutral | 27.5 | -598,096 | -17.78% | ✗ | - |
| Mar 20, 2023 | Mar 22, 2023 | Chen Bihua | 10% Owner | Buy | 100.0 | +827,100 | 29.02% | ✗ | $16.8M |
| Apr 6, 2022 | May 5, 2022 | Sturge Simon | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 6, 2022 | May 5, 2022 | Xavier Ramnik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 6, 2022 | May 5, 2022 | Moukheibir Catherine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 6, 2022 | May 5, 2022 | Phillips Andrew John | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 15, 2022 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Reich Kristian | Chief Scientific Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Santos da Silva Jorge | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Sturge Simon | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Phillips Andrew John | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Bodenstedt Matthias | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Lassen Kara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Xavier Ramnik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Loy Spike | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 15, 2022 | Moukheibir Catherine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 5, 2022 | Apr 7, 2022 | Helix Holdings LLC | Other | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 5, 2022 | Apr 7, 2022 | Chen Bihua | 10% Owner | Buy | 100.0 | +2,850,000 | 100.00% | ✗ | $28.5M |
| Oct 22, 2020 | Oct 22, 2020 | Chen Bihua | CEO | Buy | 100.0 | +430,000 | 100.00% | ✗ | $4.3M |
| Oct 22, 2020 | Oct 22, 2020 | Helix Holdings LLC | Director | Buy | 100.0 | +430,000 | 100.00% | ✗ | $4.3M |
| Oct 19, 2020 | Chen Bihua | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 19, 2020 | Lewis Will | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 19, 2020 | Helix Holdings LLC | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 19, 2020 | CHANG NANCY T | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 19, 2020 | Schmid John P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 19, 2020 | Scollins Jay | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |