2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Gordon Carl L | Director | 2,212,571 | Mar 31, 2021 |
| Orbimed Advisors Llc | Director | 2,212,571 | Mar 31, 2021 |
| OrbiMed Capital GP VI LLC | Director | 2,212,571 | Mar 31, 2021 |
| Guthart Leo | — | 1,100,446 | Nov 5, 2020 |
| Topspin Fund L.P. | — | 1,100,446 | Nov 5, 2020 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 24, 2026 | Feb 26, 2026 | Piscitelli Dominic | CFO | Sell | 10.0 | -52,000 | -43.28% | ✓ | $702.7K |
| Jan 16, 2026 | Jan 20, 2026 | Heyman Richard A. | Director | Sell | 42.5 | -6,700 | -2.56% | ✓ | $80.4K |
| Jan 2, 2026 | Jan 6, 2026 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 6, 2026 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2025 | Dec 17, 2025 | Multani Pratik S | Chief Medical Officer | Sell | 42.5 | -10,720 | -13.59% | ✗ | $97.1K |
| Dec 15, 2025 | Dec 17, 2025 | Piscitelli Dominic | CFO | Sell | 42.5 | -10,720 | -13.59% | ✗ | $97.1K |
| Dec 15, 2025 | Dec 17, 2025 | Chacko Jacob | CEO | Sell | 40.0 | -33,374 | -5.43% | ✗ | $302.4K |
| Dec 8, 2025 | Dec 9, 2025 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2025 | Dec 5, 2025 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 6, 2025 | Oct 8, 2025 | Piscitelli Dominic | CFO | Sell | 20.0 | -11,000 | -18.54% | ✓ | $159.7K |
| Oct 6, 2025 | Oct 8, 2025 | Chacko Jacob | CEO | Sell | 30.0 | -37,461 | -6.59% | ✓ | $461.5K |
| Oct 3, 2025 | Oct 3, 2025 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 30, 2025 | Oct 2, 2025 | Chacko Jacob | CEO | Sell | 20.0 | -87,539 | -13.34% | ✓ | $1.1M |
| Sep 22, 2025 | Sep 24, 2025 | Chacko Jacob | CEO | Sell | 15.0 | -125,000 | -16.00% | ✓ | $1.3M |
| Jul 1, 2025 | Jul 2, 2025 | Piscitelli Dominic | CFO | Sell | 10.0 | -20,000 | -29.28% | ✓ | $201K |
| Jun 23, 2025 | Jun 24, 2025 | Piscitelli Dominic | CFO | Sell | 7.5 | -33,500 | -32.90% | ✓ | $351.4K |
| Jun 20, 2025 | Jun 23, 2025 | You Angie | Director | Buy | 97.5 | +28,000 | 100.00% | ✗ | $262.9K |
| Jun 12, 2025 | Jun 13, 2025 | Piscitelli Dominic | CFO | Sell | 53.8 | -300 | -0.29% | ✓ | $3K |
| Jun 10, 2025 | Jun 11, 2025 | Piscitelli Dominic | CFO | Sell | 41.3 | -3,300 | -3.13% | ✓ | $33K |
| Jun 6, 2025 | Jun 9, 2025 | Piscitelli Dominic | CFO | Sell | 45.0 | -2,900 | -2.72% | ✓ | $29K |
| Mar 3, 2025 | Mar 4, 2025 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2024 | Dec 17, 2024 | Piscitelli Dominic | CFO | Sell | 42.5 | -8,851 | -7.66% | ✗ | $73.3K |
| Dec 15, 2024 | Dec 17, 2024 | Multani Pratik S | Chief Medical Officer | Sell | 42.5 | -8,850 | -15.91% | ✗ | $73.3K |
| Dec 15, 2024 | Dec 17, 2024 | Chacko Jacob | CEO | Sell | 42.5 | -24,660 | -3.07% | ✗ | $204.2K |
| Jun 12, 2024 | Jun 14, 2024 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2024 | Jun 4, 2024 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 6, 2024 | Mar 8, 2024 | Chacko Jacob | CEO | Sell | 30.0 | -40,000 | -5.20% | ✓ | $648.4K |
| Feb 6, 2024 | Feb 8, 2024 | Chacko Jacob | CEO | Sell | 35.0 | -40,000 | -4.95% | ✓ | $489.3K |
| Jan 2, 2024 | Jan 3, 2024 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2024 | Jan 3, 2024 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2024 | Jan 3, 2024 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2023 | Dec 19, 2023 | Multani Pratik S | Chief Medical Officer | Sell | 46.3 | -5,282 | -18.16% | ✗ | $45.4K |
| Dec 15, 2023 | Dec 19, 2023 | Piscitelli Dominic | CFO | Sell | 46.3 | -5,282 | -5.93% | ✗ | $45.3K |
| Dec 15, 2023 | Dec 19, 2023 | Chacko Jacob | CEO | Sell | 42.5 | -14,539 | -1.77% | ✗ | $124.8K |
| Jul 10, 2023 | Jul 11, 2023 | Chacko Jacob | CEO | Sell | 45.0 | -15,664 | -1.97% | ✓ | $125.5K |
| Jul 5, 2023 | Jul 7, 2023 | Chacko Jacob | CEO | Sell | 51.3 | -4,336 | -0.54% | ✓ | $34.7K |
| Jun 26, 2023 | Jun 28, 2023 | Chacko Jacob | CEO | Sell | 41.3 | -20,000 | -2.44% | ✓ | $160.6K |
| Jun 14, 2023 | Jun 15, 2023 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2023 | Jun 15, 2023 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2023 | Jun 15, 2023 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2023 | Jun 15, 2023 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2023 | Jun 15, 2023 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2022 | Feb 17, 2023 | Multani Pratik S | Chief Medical Officer | Sell | 47.5 | -2,227 | -23.41% | ✗ | $6.8K |
| Dec 15, 2022 | Feb 17, 2023 | Piscitelli Dominic | CFO | Sell | 47.5 | -2,227 | -3.20% | ✗ | $6.9K |
| Dec 15, 2022 | Feb 17, 2023 | Chacko Jacob | CEO | Sell | 48.8 | -6,137 | -0.75% | ✗ | $18.9K |
| Feb 1, 2023 | Feb 2, 2023 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 1, 2023 | Feb 2, 2023 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 1, 2023 | Feb 2, 2023 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2022 | Dec 16, 2022 | Multani Pratik S | Chief Medical Officer | Sell | 47.5 | -2,089 | -21.96% | ✗ | $6.8K |
| Dec 15, 2022 | Dec 16, 2022 | Piscitelli Dominic | CFO | Sell | 47.5 | -2,089 | -3.01% | ✗ | $6.8K |
| Dec 15, 2022 | Dec 16, 2022 | Chacko Jacob | CEO | Sell | 48.8 | -5,764 | -0.70% | ✗ | $18.7K |
| Jul 20, 2022 | Jul 21, 2022 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 20, 2022 | Jul 21, 2022 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 20, 2022 | Jul 21, 2022 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2022 | Jun 17, 2022 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2022 | Jun 17, 2022 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2022 | Jun 17, 2022 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2022 | Jun 17, 2022 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 17, 2022 | Jun 17, 2022 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 11, 2022 | May 13, 2022 | Chacko Jacob | CEO | Buy | 100.0 | +450,000 | 127.60% | ✗ | $1.3M |
| Mar 31, 2022 | Mar 31, 2022 | Piscitelli Dominic | CFO | Buy | 97.5 | +60,000 | 100.00% | ✗ | $321.6K |
| Mar 23, 2022 | Mar 25, 2022 | Chacko Jacob | CEO | Buy | 100.0 | +350,000 | 13197.59% | ✗ | $1.7M |
| Feb 1, 2022 | Feb 2, 2022 | Multani Pratik S | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 1, 2022 | Feb 2, 2022 | Piscitelli Dominic | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 1, 2022 | Feb 2, 2022 | Chacko Jacob | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 12, 2021 | Nov 16, 2021 | COLUMN GROUP II, LP | 10% Owner | Neutral | 27.5 | -1,026,494 | -20.24% | ✗ | - |
| Nov 9, 2021 | Nov 10, 2021 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 10, 2021 | You Angie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 14, 2021 | Sep 16, 2021 | Heyman Richard A. | Director | Sell | 51.3 | -1,388 | -0.60% | ✓ | $34.8K |
| Sep 14, 2021 | Sep 16, 2021 | Chacko Jacob | CEO | Sell | 10.0 | -8,156 | -75.46% | ✓ | $204.3K |
| Sep 10, 2021 | Sep 14, 2021 | Heyman Richard A. | Director | Sell | 52.5 | -1,080 | -0.47% | ✓ | $27.1K |
| Sep 10, 2021 | Sep 14, 2021 | Chacko Jacob | CEO | Sell | 10.0 | -5,743 | -34.70% | ✓ | $143.9K |
| Sep 7, 2021 | Sep 9, 2021 | Heyman Richard A. | Director | Sell | 52.5 | -1,086 | -0.47% | ✓ | $27.3K |
| Sep 7, 2021 | Sep 9, 2021 | Chacko Jacob | CEO | Sell | 10.0 | -6,181 | -27.19% | ✓ | $155.2K |
| Aug 13, 2021 | Aug 16, 2021 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 16, 2021 | Hoerter Steven L. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 16, 2021 | Jun 17, 2021 | Svennilson Peter | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 16, 2021 | Jun 17, 2021 | Kunkel Lori Anne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 16, 2021 | Jun 17, 2021 | Heyman Richard A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 16, 2021 | Jun 17, 2021 | GORDON CARL L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 16, 2021 | Jun 17, 2021 | Dier Mardi | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 27, 2021 | May 28, 2021 | Chacko Jacob | CEO | Sell | 48.8 | -400 | -1.73% | ✓ | $10K |