2025Q4
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Ra Capital Management, L.P. | 10% Owner | 2,727,446 | Mar 16, 2021 |
| RA Capital Healthcare Fund LP | 10% Owner | 2,727,446 | Mar 16, 2021 |
| Kolchinsky Peter | 10% Owner | 2,727,446 | Mar 16, 2021 |
| Shah Rajeev M. | 10% Owner | 2,727,446 | Mar 16, 2021 |
| Silverstein Jonathan | — | 2,576,532 | Nov 21, 2017 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Oct 7, 2025 | Oct 7, 2025 | SCHAEFFER LEONARD D | Director | Neutral | 47.5 | -111,900 | -100.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Nokes Rachael | CFO | Neutral | 47.5 | -156,061 | -100.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Tucker John H | CEO | Neutral | 47.5 | -440,847 | -100.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 7, 2025 | Oct 7, 2025 | Khattar Jack A. | Director | Neutral | 47.5 | -5,000 | -100.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 11, 2025 | Feb 12, 2025 | Tucker John H | CEO | Neutral | 27.5 | -200,000 | -31.21% | ✗ | - |
| Feb 11, 2025 | Feb 12, 2025 | Nokes Rachael | CFO | Neutral | 90.0 | +88,445 | 130.80% | ✗ | - |
| Jan 3, 2025 | Jan 7, 2025 | Nokes Rachael | CFO | Sell | 36.3 | -5,235 | -7.19% | ✓ | $18.6K |
| Jan 3, 2025 | Jan 7, 2025 | Tucker John H | CEO | Sell | 36.3 | -13,360 | -5.26% | ✓ | $47.5K |
| Aug 26, 2024 | Aug 28, 2024 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 6, 2024 | Aug 28, 2024 | Nokes Rachael | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 13, 2024 | Aug 15, 2024 | ORBIMED ADVISORS LLC | 10% Owner | Buy | 95.0 | +500,000 | 8.99% | ✗ | $2M |
| Aug 6, 2024 | Aug 8, 2024 | Nokes Rachael | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 29, 2024 | Apr 2, 2024 | Tucker John H | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 18, 2024 | Jan 22, 2024 | Nokes Rachael | CFO | Neutral | 90.0 | +41,840 | 203.44% | ✗ | - |
| Jan 18, 2024 | Jan 22, 2024 | Tucker John H | CEO | Neutral | 90.0 | +113,560 | 80.74% | ✗ | - |
| Jan 2, 2024 | Jan 3, 2024 | Nokes Rachael | CFO | Sell | 47.5 | -1,027 | -4.76% | ✗ | $6.6K |
| Jan 2, 2024 | Jan 3, 2024 | Tucker John H | CEO | Sell | 46.3 | -4,942 | -3.39% | ✗ | $31.6K |
| Jun 6, 2023 | Jun 8, 2023 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 8, 2023 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 19, 2023 | Jan 23, 2023 | Tucker John H | CEO | Neutral | 90.0 | +66,665 | 84.47% | ✗ | - |
| Feb 25, 2020 | Jan 23, 2023 | Nokes Rachael | Officer | Sell | 91.3 | +7,743 | 55.91% | ✗ | $34.4K |
| Dec 15, 2022 | Dec 19, 2022 | Nokes Rachael | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 25, 2022 | Nov 29, 2022 | ORBIMED ADVISORS LLC | 10% Owner | Buy | 100.0 | +762,380 | 16.70% | ✗ | $4M |
| Oct 6, 2022 | Oct 11, 2022 | 5AM Partners IV, LLC | 10% Owner | Sell | 17.5 | -600,000 | -17.99% | ✗ | $2.5M |
| Oct 7, 2022 | Oct 11, 2022 | Tucker John H | CEO | Sell | 42.5 | -10,288 | -11.53% | ✗ | $51.2K |
| Sep 6, 2022 | Sep 8, 2022 | 5AM Partners IV, LLC | 10% Owner | Sell | 17.5 | -226,622 | -6.36% | ✗ | $1.1M |
| Jun 14, 2022 | Jun 15, 2022 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 14, 2022 | Jun 15, 2022 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 11, 2022 | Apr 13, 2022 | 5AM Partners IV, LLC | 10% Owner | Sell | 17.5 | -270,000 | -7.05% | ✗ | $1.4M |
| Jan 31, 2022 | Feb 1, 2022 | Nokes Rachael | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 31, 2022 | Feb 1, 2022 | Tucker John H | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 3, 2021 | Dec 6, 2021 | Khattar Jack A. | Director | Buy | 91.3 | +5,000 | 100.00% | ✗ | $19.6K |
| Dec 3, 2021 | Dec 6, 2021 | Tucker John H | CEO | Buy | 91.3 | +10,000 | 27.05% | ✗ | $39.6K |
| Jun 8, 2021 | Jun 10, 2021 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 8, 2021 | Jun 10, 2021 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2021 | Mar 16, 2021 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Sell | 17.5 | -150,057 | -5.21% | ✗ | $1.1M |
| Feb 16, 2021 | Feb 17, 2021 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 17, 2021 | Abraham William Tober | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 25, 2021 | Jan 27, 2021 | Tucker John H | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 25, 2021 | Jan 27, 2021 | Nokes Rachael | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 8, 2020 | Jul 13, 2020 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 13, 2020 | Bonstein Sara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 30, 2020 | Jul 2, 2020 | Tucker John H | CEO | Sell | 42.5 | -10,288 | -21.77% | ✗ | $75.7K |
| Jun 9, 2020 | Jun 11, 2020 | Coleman Dorothy | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | Hudson Frederick M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | VEITINGER KLAUS R DR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | Khattar Jack A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | Freeman Mason | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 9, 2020 | Jun 11, 2020 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 26, 2020 | May 28, 2020 | Schwab Andrew J. | 10% Owner | Buy | 100.0 | +578,034 | 17.77% | ✗ | $5M |
| May 28, 2020 | 5AM Opportunities I (GP), LLC | Other | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| May 21, 2020 | May 26, 2020 | ORBIMED ADVISORS LLC | 10% Owner | Buy | 100.0 | +1,387,283 | 40.68% | ✗ | $12M |
| Feb 14, 2020 | Feb 21, 2020 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Buy | 95.0 | +271,993 | 8.38% | ✗ | $2.2M |
| Feb 14, 2020 | Feb 19, 2020 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | Buy | 95.0 | +271,993 | 9.14% | ✗ | $2.2M |
| Jan 10, 2020 | Jan 14, 2020 | Tucker John H | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 10, 2020 | Jan 14, 2020 | Nokes Rachael | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 13, 2019 | Dec 17, 2019 | Tucker John H | CEO | Buy | 91.3 | +5,000 | 100.00% | ✗ | $26.2K |
| Jun 18, 2019 | Jun 20, 2019 | SCHAEFFER LEONARD D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2019 | Jun 20, 2019 | Baylor-Henry Minnie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2019 | Jun 20, 2019 | Agger Mette Kirstine | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |