SPRUCE BIOSCIENCES, INC. (SPRB)

Latest Insider Confidence Score

2025Q4

45.5
Bearish

Company insider confidence (by quarter)

2020Q4 2025Q4

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Novo A/S 10% Owner 2,550,000 Mar 25, 2024
Omega Fund VI, L.P. Other 1,911,022 Oct 16, 2020
Omega Fund VI GP, L.P. 10% Owner 1,911,022 Oct 16, 2020
Omega Fund VI GP Manager, Ltd. 10% Owner 1,911,022 Oct 16, 2020
HealthCap VIII, L.P. Other 1,783,621 Oct 16, 2020

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Dec 11, 2025 Jan 21, 2026 Ways Douglas Kirk Interim Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Dec 31, 2025 Jan 5, 2026 Szwarcberg Javier B. CEO Neutral 90.0 +4,690 32.77% ✗ -
Dec 15, 2025 Dec 17, 2025 Gharib Samir M. CFO Sell 26.3 -362 -2.19% ✗ $29.2K
Dec 15, 2025 Dec 17, 2025 Szwarcberg Javier B. CEO Sell 22.5 -1,360 -4.63% ✗ $109.7K
Dec 11, 2025 Dec 15, 2025 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 SIMPSON CAMILLA V Director Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 Barretto-Ko Percival Director Neutral 52.5 - 0.00% ✗ -
Dec 11, 2025 Dec 15, 2025 Walbert Keli Director Neutral 52.5 - 0.00% ✗ -
Dec 15, 2025 Walbert Keli Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2025 Dec 12, 2025 Gharib Samir M. CFO Sell 22.5 -864 -5.81% ✗ $75.9K
Dec 10, 2025 Dec 12, 2025 Szwarcberg Javier B. CEO Sell 22.5 -2,622 -10.14% ✗ $230.6K
Oct 20, 2025 Oct 22, 2025 Gharib Samir M. CFO Sell 22.5 -661 -9.83% ✗ $97.9K
Oct 20, 2025 Oct 22, 2025 Szwarcberg Javier B. CEO Sell 22.5 -1,539 -13.97% ✗ $228K
Oct 6, 2025 Oct 15, 2025 Parkman Healthcare Partners LLC 10% Owner Sell 52.5 -1 -0.10% ✗ $335
Oct 15, 2025 Parkman Healthcare Partners LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
Oct 6, 2025 Oct 8, 2025 Parkman Healthcare Partners LLC 10% Owner Sell 52.5 -1 -0.10% ✗ $335
Oct 8, 2025 Parkman Healthcare Partners LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 SIMPSON CAMILLA V Director Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 Barretto-Ko Percival Director Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 Aynechi Tiba Director Neutral 52.5 - 0.00% ✗ -
Jul 23, 2025 Jul 24, 2025 Ways Kirk Interim Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jul 22, 2025 Jul 24, 2025 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 20, 2024 Charlton Ralph William III CHIEF MEDICAL OFFICER Sell 26.3 -58,784 -12.12% ✗ $28.5K
Dec 10, 2024 Dec 20, 2024 Gharib Samir M. CFO Sell 26.3 -81,976 -7.73% ✗ $40K
Dec 10, 2024 Dec 20, 2024 Szwarcberg Javier B. CEO Sell 22.5 -199,630 -14.25% ✗ $96.6K
May 22, 2024 May 24, 2024 Ways Kirk Director Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 SIMPSON CAMILLA V Director Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 Barretto-Ko Percival Director Neutral 52.5 - 0.00% ✗ -
May 22, 2024 May 24, 2024 Aynechi Tiba Director Neutral 52.5 - 0.00% ✗ -
Mar 21, 2024 Mar 25, 2024 Novo Holdings A/S 10% Owner Sell 20.0 -465,021 -15.42% ✗ $351K
Mar 18, 2024 Mar 20, 2024 Novo Holdings A/S 10% Owner Sell 17.5 -1,794,999 -37.32% ✗ $1.4M
Mar 14, 2024 Mar 18, 2024 Novo Holdings A/S 10% Owner Sell 17.5 -1,912,316 -28.45% ✗ $1.7M
Mar 14, 2024 Mar 18, 2024 Charlton Ralph William III CHIEF MEDICAL OFFICER Neutral 52.5 - 0.00% ✗ -
Mar 14, 2024 Mar 18, 2024 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Mar 14, 2024 Mar 18, 2024 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Dec 29, 2023 Jan 3, 2024 Charlton Ralph William III Chief Medical Officer Neutral 90.0 +9,361 20.34% ✗ -
Dec 29, 2023 Jan 3, 2024 Gharib Samir M. CFO Neutral 85.0 +11,255 5.88% ✗ -
Dec 15, 2023 Dec 18, 2023 Charlton Ralph William III Chief Medical Officer Sell 26.3 -10,980 -19.27% ✗ $18.2K
Dec 15, 2023 Dec 18, 2023 Gharib Samir M. CFO Sell 22.5 -36,095 -9.14% ✗ $59.9K
Dec 15, 2023 Dec 18, 2023 Szwarcberg Javier B. CEO Sell 22.5 -38,384 -26.34% ✗ $63.7K
Nov 26, 2023 Nov 28, 2023 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Nov 8, 2023 Nov 13, 2023 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jul 5, 2023 Charlton Ralph William III Chief Medical Officer Neutral 90.0 +12,378 96.22% ✗ -
Jun 30, 2023 Jul 5, 2023 Szwarcberg Javier B. CEO Neutral 90.0 +20,000 136.01% ✗ -
Jun 30, 2023 Jul 5, 2023 Gharib Samir M. CFO Sell 22.5 -15,452 -7.84% ✗ $55.8K
May 25, 2023 May 26, 2023 Ways Kirk Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 SIMPSON CAMILLA V Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 O'Donnell Niall Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 Aynechi Tiba Director Neutral 52.5 - 0.00% ✗ -
May 25, 2023 May 26, 2023 Barretto-Ko Percival Director Neutral 52.5 - 0.00% ✗ -
May 26, 2023 Barretto-Ko Percival Director Neutral 52.5 - 0.00% ✗ -
Feb 16, 2023 May 16, 2023 O'Donnell Niall Director Buy 100.0 +630,400 90.59% ✗ $2M
Feb 16, 2023 Feb 21, 2023 Novo Holdings A/S 10% Owner Buy 100.0 +2,208,000 48.91% ✗ $7M
Dec 30, 2022 Jan 5, 2023 Charlton Ralph William III Chief Medical Officer Neutral 90.0 +12,864 100.00% ✗ -
Dec 30, 2022 Jan 5, 2023 Szwarcberg Javier B. CEO Neutral 90.0 +14,705 100.00% ✗ -
Dec 30, 2022 Jan 5, 2023 Gharib Samir M. CFO Sell 26.3 -15,292 -14.60% ✗ $17.6K
Dec 5, 2022 Dec 7, 2022 Charlton Ralph William III Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Dec 5, 2022 Dec 7, 2022 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Dec 5, 2022 Dec 7, 2022 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Jul 5, 2022 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Jun 30, 2022 Jul 5, 2022 Gharib Samir M. CFO Sell 26.3 -7,522 -18.29% ✗ $22.6K
May 25, 2022 May 27, 2022 Aynechi Tiba Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 O'Donnell Niall Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 Ways Kirk Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 Chaya Moghrabi Dina Director Neutral 52.5 - 0.00% ✗ -
May 25, 2022 May 27, 2022 SIMPSON CAMILLA V Director Neutral 52.5 - 0.00% ✗ -
Apr 1, 2022 Apr 1, 2022 Charlton Ralph William III Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Apr 1, 2022 Charlton Ralph William III Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 3, 2022 Jan 10, 2022 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Jan 10, 2022 Szwarcberg Javier B. CEO Neutral 52.5 - 0.00% ✗ -
Dec 31, 2021 Jan 5, 2022 Gharib Samir M. CFO Buy 90.0 +2,220 92.04% ✗ $8.4K
Dec 16, 2021 Dec 20, 2021 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Dec 16, 2021 Dec 20, 2021 Gharib Samir M. CFO Neutral 52.5 - 0.00% ✗ -
Dec 16, 2021 Dec 20, 2021 Dias Subaweerage Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jun 30, 2021 Jul 6, 2021 KING RICHARD CEO Buy 91.3 +2,230 100.00% ✗ $21.2K
Jun 30, 2021 Jul 6, 2021 Gharib Samir M. CFO Buy 91.3 +1,412 100.00% ✗ $13.5K
Jun 23, 2021 Jun 25, 2021 Ways Kirk Director Neutral 52.5 - 0.00% ✗ -
Jun 25, 2021 Ways Kirk Director Neutral 52.5 - 0.00% ✗ -
May 20, 2021 May 21, 2021 SPIEGELMAN DANIEL K Director Neutral 52.5 - 0.00% ✗ -
May 20, 2021 May 21, 2021 SIMPSON CAMILLA V Director Sell 15.0 -334 -100.00% ✓ $5.1K
May 20, 2021 May 21, 2021 O'Donnell Niall Director Neutral 52.5 - 0.00% ✗ -
May 20, 2021 May 21, 2021 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
May 20, 2021 May 21, 2021 Chaya Moghrabi Dina Director Neutral 52.5 - 0.00% ✗ -
May 20, 2021 May 21, 2021 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
May 19, 2021 May 21, 2021 Novo Holdings A/S 10% Owner Sell 16.3 -475,000 -9.52% ✗ $6.6M
Apr 30, 2021 May 4, 2021 SIMPSON CAMILLA V Director Sell 10.0 -14,045 -100.00% ✓ $226.7K