Spyre Therapeutics, Inc. (SYRE)

Latest Insider Confidence Score

2026Q1

48.0
Bearish

Company insider confidence (by quarter)

2016Q2 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Kiselak Tomas — 9,460,540 Jun 30, 2023
Fairmount Funds Management LLC — 9,460,540 Jun 30, 2023
Fairmount Healthcare Fund II L.P. — 9,460,540 Jun 30, 2023
Harwin Peter Evan — 9,460,540 Jun 30, 2023
Fairmount Healthcare Fund L.P. — 9,460,540 Jun 30, 2023

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Mar 3, 2026 Mar 3, 2026 Burrows Scott L CFO Sell 42.5 -2,500 -2.49% ✓ $101.6K
Mar 2, 2026 Mar 3, 2026 Turtle Cameron CEO Sell 41.3 -15,000 -2.28% ✓ $632.9K
Feb 2, 2026 Feb 4, 2026 Turtle Cameron CEO Sell 41.3 -15,000 -2.23% ✓ $492K
Jan 21, 2026 Jan 23, 2026 HENDERSON MICHAEL THOMAS Director Neutral 90.0 +63,227 60.00% ✗ -
Jan 9, 2026 Jan 13, 2026 Burrows Scott L CFO Neutral 52.5 - 0.00% ✗ -
Jan 9, 2026 Jan 13, 2026 Turtle Cameron CEO Neutral 52.5 - 0.00% ✗ -
Jan 9, 2026 Jan 13, 2026 Sloan Sheldon Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 9, 2026 Jan 13, 2026 King-Jones Heidy Officer Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Turtle Cameron CEO Sell 41.3 -15,000 -2.18% ✓ $460.1K
Dec 1, 2025 Dec 3, 2025 Turtle Cameron CEO Sell 38.8 -15,000 -2.14% ✓ $435.4K
Nov 3, 2025 Nov 5, 2025 Turtle Cameron CEO Sell 27.5 -45,000 -6.02% ✓ $1M
Sep 2, 2025 Sep 3, 2025 Burrows Scott L CFO Sell 40.0 -18,428 -15.83% ✗ $299.6K
May 29, 2025 Jun 2, 2025 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
May 29, 2025 Jun 2, 2025 Stelzer Laurie Director Neutral 52.5 - 0.00% ✗ -
May 29, 2025 Jun 2, 2025 Milligan Sandra Director Neutral 52.5 - 0.00% ✗ -
May 29, 2025 Jun 2, 2025 McKenna Mark C. Director Neutral 52.5 - 0.00% ✗ -
May 29, 2025 Jun 2, 2025 HENDERSON MICHAEL THOMAS Director Neutral 52.5 - 0.00% ✗ -
May 29, 2025 Jun 2, 2025 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
Jan 15, 2025 Jan 17, 2025 Burrows Scott L CFO Neutral 52.5 - 0.00% ✗ -
Jan 15, 2025 Jan 17, 2025 Sloan Sheldon Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 15, 2025 Jan 17, 2025 Turtle Cameron CEO Neutral 52.5 - 0.00% ✗ -
Jan 15, 2025 Jan 17, 2025 King-Jones Heidy Officer Neutral 52.5 - 0.00% ✗ -
Jan 10, 2025 Jan 14, 2025 HENDERSON MICHAEL THOMAS Director Neutral 90.0 +105,379 100.00% ✗ -
Nov 6, 2024 Nov 8, 2024 Albers Jeffrey W. Director Sell 20.0 -6,700 -19.67% ✓ $246.3K
Oct 25, 2024 Oct 28, 2024 Albers Jeffrey W. Director Sell 51.3 -300 -0.87% ✓ $10.9K
Oct 1, 2024 Oct 1, 2024 Sloan Sheldon Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Oct 1, 2024 Sloan Sheldon Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Sep 3, 2024 Sep 5, 2024 Burrows Scott L CFO Sell 40.0 -18,531 -13.73% ✗ $522.1K
May 14, 2024 May 16, 2024 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
May 14, 2024 May 16, 2024 Milligan Sandra Director Neutral 52.5 - 0.00% ✗ -
May 14, 2024 May 16, 2024 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
May 14, 2024 May 16, 2024 Stelzer Laurie Director Neutral 52.5 - 0.00% ✗ -
May 14, 2024 May 16, 2024 HENDERSON MICHAEL THOMAS Director Neutral 52.5 - 0.00% ✗ -
May 16, 2024 Milligan Sandra Director Neutral 52.5 - 0.00% ✗ -
Apr 25, 2024 Apr 25, 2024 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
Feb 15, 2024 Feb 20, 2024 Turtle Cameron CEO Neutral 55.0 +400 0.05% ✗ -
Feb 1, 2024 Feb 5, 2024 McKenna Mark C. Director Neutral 52.5 - 0.00% ✗ -
Feb 5, 2024 McKenna Mark C. Director Neutral 52.5 - 0.00% ✗ -
Feb 1, 2024 Feb 2, 2024 Turtle Cameron CEO Neutral 52.5 - 0.00% ✗ -
Feb 1, 2024 Feb 2, 2024 Burrows Scott L CFO Neutral 52.5 - 0.00% ✗ -
Feb 1, 2024 Feb 2, 2024 King-Jones Heidy Officer Neutral 52.5 - 0.00% ✗ -
Dec 29, 2023 Dec 29, 2023 Fairmount Funds Management LLC Director Neutral 15.0 -2,623,404 -68.79% ✓ -
Dec 22, 2023 Dec 22, 2023 Burrows Scott L CFO Neutral 90.0 +134,953 100.00% ✗ -
Dec 7, 2023 Dec 11, 2023 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
Nov 24, 2023 Dec 8, 2023 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
Dec 8, 2023 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
Nov 24, 2023 Nov 28, 2023 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
Nov 22, 2023 Nov 27, 2023 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
Nov 22, 2023 Nov 27, 2023 Stelzer Laurie Director Neutral 52.5 - 0.00% ✗ -
Nov 27, 2023 Albers Jeffrey W. Director Neutral 52.5 - 0.00% ✗ -
Nov 27, 2023 Stelzer Laurie Director Neutral 52.5 - 0.00% ✗ -
Nov 24, 2023 Nov 27, 2023 Turtle Cameron CEO Neutral 52.5 - 0.00% ✗ -
Sep 1, 2023 Sep 5, 2023 King-Jones Heidy Officer Neutral 52.5 - 0.00% ✗ -
Sep 5, 2023 King-Jones Heidy Officer Neutral 52.5 - 0.00% ✗ -
Sep 1, 2023 Sep 5, 2023 Burrows Scott L CFO Neutral 52.5 - 0.00% ✗ -
Sep 5, 2023 Burrows Scott L CFO Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Fairmount Funds Management LLC Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Turtle Cameron COO Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 HENDERSON MICHAEL THOMAS Director Neutral 52.5 - 0.00% ✗ -
Jun 22, 2023 Jun 30, 2023 Alspaugh Jonathan CFO Neutral 52.5 - 0.00% ✗ -
Jun 22, 2023 Jun 30, 2023 Cox Russell J. Director Neutral 52.5 - 0.00% ✗ -
Jun 22, 2023 Jun 30, 2023 Magovcevic-Liebisch Ivana Director Neutral 52.5 - 0.00% ✗ -
Jun 22, 2023 Jun 30, 2023 Smith Hunter C Director Neutral 52.5 - 0.00% ✗ -
Jun 22, 2023 Jun 30, 2023 Lawton Alison Frances Director Neutral 52.5 - 0.00% ✗ -
Feb 23, 2023 Feb 24, 2023 Neuman Linda L Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Feb 23, 2023 Feb 24, 2023 Kastenmayer James Paul General Counsel Neutral 52.5 - 0.00% ✗ -
Feb 23, 2023 Feb 24, 2023 Hanley Jr. Michael Conick Chief Business Officer Neutral 52.5 - 0.00% ✗ -
Feb 23, 2023 Feb 24, 2023 Alspaugh Jonathan CFO Neutral 52.5 - 0.00% ✗ -
Nov 14, 2022 Jan 27, 2023 Neuman Linda L Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 27, 2023 Neuman Linda L Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Nov 29, 2022 Dec 1, 2022 Goldberg Jeff Marc CEO Neutral 52.5 - 0.00% ✗ -
Dec 1, 2022 Goldberg Jeff Marc CEO Neutral 52.5 - 0.00% ✗ -
Aug 23, 2022 Aug 25, 2022 Kastenmayer James Paul CEO Neutral 52.5 - 0.00% ✗ -
Aug 25, 2022 Kastenmayer James Paul CEO Neutral 52.5 - 0.00% ✗ -
Aug 25, 2022 Aug 25, 2022 Souza Marcio Director Buy 95.0 +90,000 100.00% ✗ $50.5K
Aug 23, 2022 Aug 25, 2022 Sloan Leslie COO Neutral 52.5 - 0.00% ✗ -
Aug 23, 2022 Aug 25, 2022 Hanley Jr. Michael Conick Chief Business Officer Neutral 52.5 - 0.00% ✗ -
Aug 23, 2022 Aug 25, 2022 Alspaugh Jonathan CFO Neutral 52.5 - 0.00% ✗ -
Jun 8, 2022 Jun 10, 2022 Hanley Jr. Michael Conick Chief Commercial Officer Buy 91.3 +28,200 352.50% ✗ $20K
Jun 7, 2022 Jun 10, 2022 Lawton Alison Frances Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Shanafelt Armen Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Souza Marcio Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Smith Hunter C Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Mahatme Sandesh Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Magovcevic-Liebisch Ivana Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 LAWLIS V BRYAN Director Neutral 52.5 - 0.00% ✗ -
Jun 7, 2022 Jun 9, 2022 Cox Russell J. Director Neutral 52.5 - 0.00% ✗ -
Mar 16, 2022 Mar 18, 2022 Quinn Anthony G. CEO Buy 95.0 +80,079 10.87% ✗ $187.7K
Mar 11, 2022 Mar 15, 2022 Quinn Anthony G. CEO Buy 97.5 +144,666 24.31% ✗ $280.9K
Mar 11, 2022 Mar 15, 2022 Alspaugh Jonathan CFO Buy 95.0 +75,000 82.99% ✗ $156K
Feb 17, 2022 Feb 22, 2022 Quinn Anthony G. CEO Neutral 52.5 - 0.00% ✗ -
Feb 17, 2022 Feb 22, 2022 Weber Steven VP, Controller&Princ Acctg Off Neutral 52.5 - 0.00% ✗ -
Feb 17, 2022 Feb 22, 2022 Sloan Leslie COO Neutral 52.5 - 0.00% ✗ -
Feb 17, 2022 Feb 22, 2022 Hanley Jr. Michael Conick Chief Commercial Officer Neutral 52.5 - 0.00% ✗ -
Feb 17, 2022 Feb 22, 2022 Alspaugh Jonathan CFO Neutral 52.5 - 0.00% ✗ -
Dec 28, 2018 Feb 14, 2022 Quinn Anthony G. CEO Neutral 52.5 - 0.00% ✗ -
Dec 9, 2021 Dec 13, 2021 Shanafelt Armen Director Buy 97.5 +150,000 100.00% ✗ $549.7K
Dec 9, 2021 Dec 13, 2021 Quinn Anthony G. CEO Buy 90.0 +53,634 9.91% ✗ $199K
Dec 9, 2021 Dec 13, 2021 Alspaugh Jonathan CFO Buy 95.0 +50,000 123.85% ✗ $186K
Nov 12, 2021 Nov 16, 2021 Smith Hunter C Director Neutral 52.5 - 0.00% ✗ -