Upstream Bio, Inc. (UPB)

Latest Insider Confidence Score

2026Q1

50.2
Bullish

Company insider confidence (by quarter)

2024Q4 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
AI Upstream LLC 10% Owner 1,172,410 Oct 17, 2024
AI Biotechnology LLC 10% Owner 1,172,410 Oct 17, 2024
Access Industries Holdings LLC 10% Owner 1,172,410 Oct 17, 2024
Access Industries Management, Llc 10% Owner 1,172,410 Oct 17, 2024
Blavatnik Len 10% Owner 1,172,410 Oct 17, 2024

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Jan 2, 2026 Jan 6, 2026 GRAY MICHAEL CFO Neutral 90.0 +30,500 100.00% -
Jan 2, 2026 Jan 6, 2026 Deykin Aaron Chief Medical Officer Neutral 90.0 +32,000 2024.04% -
Jan 2, 2026 Jan 6, 2026 Ambrose Allison General Counsel Neutral 90.0 +17,000 100.00% -
Jan 2, 2026 Jan 6, 2026 Houghton Adam Chief Business Officer Neutral 90.0 +25,000 100.00% -
Jan 2, 2026 Jan 6, 2026 Sutherland Everett Rand CEO Neutral 90.0 +75,000 100.00% -
Jun 10, 2025 Jun 12, 2025 Renaud Ronald C JR Director Neutral 52.5 - 0.00% -
Jun 10, 2025 Jun 12, 2025 Chimovits Erez Director Neutral 52.5 - 0.00% -
Jun 10, 2025 Jun 12, 2025 Ruddy Marcella K. Director Neutral 52.5 - 0.00% -
Jun 10, 2025 Jun 12, 2025 Beckman Daniella Director Neutral 52.5 - 0.00% -
Jun 10, 2025 Jun 12, 2025 Fleming Harold Edward Director Neutral 52.5 - 0.00% -
Jun 10, 2025 Jun 12, 2025 Ratcliffe Liam Director Neutral 52.5 - 0.00% -
Feb 6, 2025 Feb 7, 2025 Sutherland Everett Rand CEO Neutral 52.5 - 0.00% -
Feb 6, 2025 Feb 7, 2025 GRAY MICHAEL CFO Neutral 52.5 - 0.00% -
Feb 6, 2025 Feb 7, 2025 Houghton Adam Chief Business Officer Neutral 52.5 - 0.00% -
Feb 6, 2025 Feb 7, 2025 Deykin Aaron Chief Medical Officer Neutral 52.5 - 0.00% -
Feb 6, 2025 Feb 7, 2025 Ambrose Allison General Counsel Neutral 52.5 - 0.00% -
Dec 16, 2024 Dec 17, 2024 Ambrose Allison General Counsel Neutral 52.5 - 0.00% -
Dec 17, 2024 Ambrose Allison General Counsel Neutral 52.5 - 0.00% -
Oct 15, 2024 Oct 17, 2024 Chimovits Erez Director Buy 100.0 +825,000 16.95% $14M
Oct 15, 2024 Oct 17, 2024 ORBIMED ADVISORS LLC Director Buy 100.0 +825,000 16.95% $14M
Oct 15, 2024 Oct 17, 2024 AI Upstream LLC 10% Owner Buy 100.0 +1,175,000 100.00% $20M
Oct 15, 2024 Oct 15, 2024 Wellington Biomedical Innovation Master Investors (Cayman) II L.P. 10% Owner Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Chimovits Erez Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Ruddy Marcella K. Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Fleming Harold Edward Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Renaud Ronald C JR Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Beckman Daniella Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Oct 15, 2024 Ratcliffe Liam Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Wellington Biomedical Innovation Master Investors (Cayman) II L.P. 10% Owner Neutral 52.5 - 0.00% -
Oct 10, 2024 Sutherland Everett Rand CEO Neutral 52.5 - 0.00% -
Oct 10, 2024 Chimovits Erez Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Beckman Daniella Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Houghton Adam Chief Business Officer Neutral 52.5 - 0.00% -
Oct 10, 2024 Ruddy Marcella K. Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Ratcliffe Liam Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Deykin Aaron Chief Medical Officer Neutral 52.5 - 0.00% -
Oct 10, 2024 Fleming Harold Edward Director Neutral 52.5 - 0.00% -
Oct 10, 2024 Renaud Ronald C JR Director Neutral 52.5 - 0.00% -
Oct 10, 2024 ORBIMED ADVISORS LLC Director Neutral 52.5 - 0.00% -
Oct 10, 2024 GRAY MICHAEL CFO Neutral 52.5 - 0.00% -
Oct 10, 2024 AI Upstream LLC 10% Owner Neutral 52.5 - 0.00% -