Zymeworks Inc. (ZYME)

Latest Insider Confidence Score

2026Q1

45.3
Bearish

Company insider confidence (by quarter)

2022Q4 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Redmile Group, LLC 10% Owner 6,075,918 Oct 18, 2022
Green Jeremy 10% Owner 6,075,918 Oct 18, 2022
EcoR1 Capital, LLC Director 5,086,521 Jun 27, 2025
Nodelman Oleg Director 5,086,521 Jun 27, 2025
Hollywood Mark — 121,367 Jan 13, 2026

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Feb 2, 2026 Mekan Sabeen SVP & Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 13, 2026 Hollywood Mark COO Sell 42.5 -6,120 -4.40% ✗ $138.8K
Jan 13, 2026 Hollywood Mark COO Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 13, 2026 Cherry Brian N Director Neutral 52.5 - 0.00% ✗ -
Jan 13, 2026 Cherry Brian N Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Smith Jeffrey T L EVP & Chief Medical Officer Sell 42.5 -9,310 -25.85% ✗ $211.1K
Jan 12, 2026 Jan 12, 2026 Ciongoli Gregory Austin Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Neu Kelvin Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Landry Robert E Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Cesano Alessandra Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Campoy Carlos Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Mahony Susan Director Neutral 52.5 - 0.00% ✗ -
Jan 12, 2026 Jan 12, 2026 Moore Paul Andrew Chief Scientific Officer Sell 42.5 -9,560 -16.47% ✗ $216.8K
Jan 12, 2026 Jan 12, 2026 Galbraith Kenneth CEO Sell 40.0 -30,424 -11.83% ✗ $689.8K
Jan 6, 2026 Jan 7, 2026 PATTERSON LEONE D EVP, Chief Bus & Fin Officer Neutral 90.0 +459 100.00% ✗ -
Jan 5, 2026 Jan 5, 2026 Smith Jeffrey T L EVP & Chief Medical Officer Sell 40.0 -10,538 -36.48% ✗ $264.5K
Jan 5, 2026 Jan 5, 2026 Galbraith Kenneth CEO Sell 37.5 -54,343 -13.39% ✗ $1.4M
Jan 5, 2026 Jan 5, 2026 Moore Paul Andrew Chief Scientific Officer Sell 40.0 -20,110 -21.93% ✗ $504.7K
Dec 22, 2025 Dec 22, 2025 Galbraith Kenneth CEO Sell 37.5 -47,528 -26.29% ✗ $1.3M
Aug 12, 2025 Aug 12, 2025 Ciongoli Gregory Austin Director Neutral 90.0 +415,000 528.66% ✗ -
Aug 11, 2025 Aug 12, 2025 Landry Robert E Director Neutral 52.5 - 0.00% ✗ -
Aug 12, 2025 Landry Robert E Director Neutral 52.5 - 0.00% ✗ -
Aug 12, 2025 Ciongoli Gregory Austin Director Neutral 52.5 - 0.00% ✗ -
Jun 26, 2025 Jun 27, 2025 EcoR1 Capital, LLC Director Sell 52.5 -41 0.00% ✗ $521.1
May 15, 2025 May 19, 2025 EcoR1 Capital, LLC Director Buy 67.5 +55,421 0.31% ✗ $635.6K
Apr 16, 2025 Apr 18, 2025 EcoR1 Capital, LLC Director Buy 77.5 +128,713 0.73% ✗ $1.5M
Apr 3, 2025 Apr 7, 2025 EcoR1 Capital, LLC Director Buy 87.5 +317,208 1.82% ✗ $3.6M
Mar 31, 2025 Apr 2, 2025 EcoR1 Capital, LLC Director Buy 77.5 +127,415 0.74% ✗ $1.5M
Mar 25, 2025 Mar 27, 2025 EcoR1 Capital, LLC Director Buy 77.5 +97,349 0.57% ✗ $1.2M
Mar 20, 2025 Mar 24, 2025 EcoR1 Capital, LLC Director Buy 77.5 +127,198 0.75% ✗ $1.6M
Mar 17, 2025 Mar 19, 2025 EcoR1 Capital, LLC Director Buy 87.5 +228,463 1.36% ✗ $2.9M
Mar 11, 2025 Mar 13, 2025 EcoR1 Capital, LLC Director Buy 97.5 +1,081,980 6.88% ✗ $13.1M
Feb 18, 2025 NODELMAN OLEG Director Neutral 52.5 - 0.00% ✗ -
Jan 16, 2025 Jan 21, 2025 EcoR1 Capital, LLC Director Buy 77.5 +141,429 0.91% ✗ $2M
Jan 13, 2025 Jan 15, 2025 EcoR1 Capital, LLC Director Buy 87.5 +167,654 1.09% ✗ $2.3M
Jan 8, 2025 Jan 10, 2025 EcoR1 Capital, LLC Director Buy 87.5 +225,119 1.48% ✗ $3M
Jan 10, 2025 Jan 10, 2025 PATTERSON LEONE D EVP, Chief Bus & Fin Officer Neutral 52.5 - 0.00% ✗ -
Jan 10, 2025 Jan 10, 2025 Moore Paul Andrew Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Jan 10, 2025 Jan 10, 2025 Smith Jeffrey T L EVP & Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 10, 2025 Jan 10, 2025 Galbraith Kenneth CEO Neutral 52.5 - 0.00% ✗ -
Jan 6, 2025 Jan 6, 2025 Moore Paul Andrew Chief Scientific Officer Sell 40.0 -21,200 -35.77% ✗ $316.4K
Jan 6, 2025 Jan 6, 2025 Galbraith Kenneth CEO Sell 40.0 -57,291 -30.86% ✗ $855K
Jan 6, 2025 Jan 6, 2025 Smith Jeffrey T L EVP & Chief Medical Officer Sell 42.5 -11,110 -55.55% ✗ $165.8K
Dec 30, 2024 Jan 2, 2025 EcoR1 Capital, LLC Director Buy 88.8 +363,369 2.45% ✗ $5.3M
Dec 24, 2024 Dec 27, 2024 EcoR1 Capital, LLC Director Buy 77.5 +130,309 0.89% ✗ $1.9M
Dec 19, 2024 Dec 26, 2024 EcoR1 Capital, LLC Director Buy 97.5 +1,254,808 9.34% ✗ $17.5M
Dec 26, 2023 Dec 23, 2024 EcoR1 Capital, LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Miller Derek John Michael Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Campoy Carlos Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Cesano Alessandra Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Neu Kelvin Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Davidson Nancy Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Cox Troy Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Mahony Susan Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2024 Dec 12, 2024 Gallagher Neil Director Neutral 52.5 - 0.00% ✗ -
Sep 1, 2024 Sep 3, 2024 PATTERSON LEONE D EVP, Chief Bus & Fin Officer Neutral 52.5 - 0.00% ✗ -
Sep 3, 2024 PATTERSON LEONE D EVP, Chief Bus & Fin Officer Neutral 52.5 - 0.00% ✗ -
Apr 2, 2024 Apr 2, 2024 Gallagher Neil Director Neutral 52.5 - 0.00% ✗ -
Apr 2, 2024 Gallagher Neil Director Neutral 52.5 - 0.00% ✗ -
Mar 4, 2024 Platshon Scott Director Neutral 52.5 - 0.00% ✗ -
Feb 8, 2024 Feb 9, 2024 Cesano Alessandra Director Neutral 52.5 - 0.00% ✗ -
Feb 9, 2024 Cesano Alessandra Director Neutral 52.5 - 0.00% ✗ -
Jan 5, 2024 Jan 8, 2024 Galbraith Kenneth CEO Sell 40.0 -23,904 -50.15% ✗ $257.8K
Jan 5, 2024 Jan 8, 2024 Astle Christopher CFO Sell 42.5 -5,994 -47.96% ✗ $64.7K
Jan 5, 2024 Jan 8, 2024 Moore Paul Andrew Chief Scientific Officer Sell 42.5 -9,799 -57.08% ✗ $105.7K
Jan 5, 2024 Jan 8, 2024 Smith Jeffrey T L EVP & Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Jan 5, 2024 Smith Jeffrey T L EVP & Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Dec 26, 2023 Dec 28, 2023 EcoR1 Capital, LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
Dec 11, 2023 Dec 11, 2023 Astle Christopher CFO Sell 47.5 -886 -30.73% ✗ $8.1K
Dec 7, 2023 Dec 8, 2023 Campoy Carlos Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 RENTON HOLLINGS Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Neu Kelvin Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Cox Troy Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Mahony Susan Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Miller Derek John Michael Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Davidson Nancy Director Neutral 52.5 - 0.00% ✗ -
Dec 7, 2023 Dec 8, 2023 Hillan Kenneth J. Director Neutral 52.5 - 0.00% ✗ -
Dec 8, 2023 Davidson Nancy Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Jun 30, 2023 Campoy Carlos Director Neutral 52.5 - 0.00% ✗ -
Jun 30, 2023 Campoy Carlos Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 EcoR1 Capital, LLC 10% Owner Buy 100.0 +3,350,000 33.21% ✗ $27.2M
Apr 10, 2023 Apr 10, 2023 Miller Derek John Michael Director Neutral 52.5 - 0.00% ✗ -
Apr 10, 2023 Miller Derek John Michael Director Neutral 52.5 - 0.00% ✗ -
Mar 28, 2023 Mar 30, 2023 EcoR1 Capital, LLC 10% Owner Buy 87.5 +200,000 2.02% ✗ $1.6M
Mar 10, 2023 Mar 14, 2023 Klompas Neil A COO Sell 46.3 -2,977 -14.38% ✗ $23.3K
Jan 19, 2023 Jan 23, 2023 EcoR1 Capital, LLC 10% Owner Buy 92.5 +307,500 3.21% ✗ $3M
Jan 13, 2023 Jan 18, 2023 EcoR1 Capital, LLC 10% Owner Buy 100.0 +985,100 11.46% ✗ $9.7M
Jan 10, 2023 Jan 12, 2023 EcoR1 Capital, LLC 10% Owner Buy 100.0 +1,026,300 13.56% ✗ $7.9M
Jan 5, 2023 Jan 6, 2023 Klompas Neil A COO Neutral 52.5 - 0.00% ✗ -
Jan 5, 2023 Jan 6, 2023 Astle Christopher CFO Neutral 52.5 - 0.00% ✗ -
Jan 5, 2023 Jan 6, 2023 Galbraith Kenneth CEO Neutral 52.5 - 0.00% ✗ -
Jan 5, 2023 Jan 6, 2023 Moore Paul Andrew Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Dec 12, 2022 Dec 23, 2022 Astle Christopher CFO Sell 15.0 -887 -39.95% ✓ $5.3K
Nov 10, 2022 Dec 23, 2022 Josephson Neil Chief Medical Officer Sell 28.8 -2,475 -14.62% ✓ $20K
Dec 22, 2022 Dec 23, 2022 Galbraith Kenneth CEO Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 23, 2022 Sacks Natalie Director Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 23, 2022 Mahony Susan Director Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 23, 2022 Cox Troy Director Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 23, 2022 Zoth Lota S. Director Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 23, 2022 Neu Kelvin Director Neutral 52.5 - 0.00% ✗ -