2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Royal Dutch Shell plc | — | 5,573,319 | Jun 3, 2011 |
| Ispagnac Participacoes Ltda. | — | 5,573,319 | Jun 3, 2011 |
| Shell Brazil Holding B.V. | — | 5,573,319 | Jun 2, 2011 |
| Equilon Enterprises LLC | — | 5,573,319 | May 24, 2011 |
| Biomedical Sciences Investment Fund Pte Ltd. | — | 3,358,522 | Apr 29, 2010 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 24, 2026 | Feb 25, 2026 | Lutz Stefan | Chief Scientific Officer | Sell | 47.5 | -5,862 | -4.30% | ✗ | $6.6K |
| Feb 23, 2026 | Feb 25, 2026 | MOORE ALISON | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 23, 2026 | Feb 25, 2026 | Erbez Georgia | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 6, 2026 | Feb 9, 2026 | Lutz Stefan | Chief Scientific Officer | Sell | 47.5 | -2,492 | -1.80% | ✗ | $3.3K |
| Feb 6, 2026 | Feb 9, 2026 | Erbez Georgia | Officer | Sell | 47.5 | -3,826 | -5.42% | ✗ | $5K |
| Feb 6, 2026 | Feb 9, 2026 | MOORE ALISON | CEO | Sell | 47.5 | -3,826 | -1.50% | ✗ | $5K |
| Jan 7, 2026 | Jan 8, 2026 | Lutz Stefan | CSO | Sell | 27.5 | -4,685 | -3.27% | ✗ | $7.9K |
| Nov 26, 2025 | Dec 15, 2025 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -514,341 | -4.83% | ✗ | $877.8K |
| Nov 7, 2025 | Dec 15, 2025 | Opaleye Management Inc. | 10% Owner | Sell | 17.5 | -1,063,211 | -8.01% | ✗ | $1.9M |
| Nov 26, 2025 | Dec 1, 2025 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -217,705 | -2.10% | ✗ | $361.3K |
| Nov 21, 2025 | Nov 25, 2025 | WOLF DENNIS P | Director | Sell | 26.3 | -8,952 | -6.05% | ✗ | $14K |
| Nov 13, 2025 | Nov 17, 2025 | MOORE ALISON | CEO | Neutral | 90.0 | +85,000 | 50.20% | ✗ | - |
| Nov 17, 2025 | Lutz Stefan | CSO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 12, 2025 | Nov 14, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 95.0 | +697,541 | 7.01% | ✗ | $1.3M |
| Nov 11, 2025 | Nov 13, 2025 | De Vre Raymond | Director | Sell | 27.5 | -1,413 | -1.59% | ✗ | $2.5K |
| Nov 11, 2025 | Nov 12, 2025 | DILLY STEPHEN GEORGE | Director | Neutral | 85.0 | +50,000 | 7.38% | ✗ | - |
| Nov 7, 2025 | Nov 12, 2025 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -469,847 | -3.71% | ✗ | $861.4K |
| Oct 13, 2025 | Oct 15, 2025 | MOORE ALISON | Chief Technical Officer | Sell | 46.3 | -6,239 | -3.55% | ✗ | $15.6K |
| Oct 13, 2025 | Oct 15, 2025 | Erbez Georgia | CFO | Sell | 46.3 | -6,239 | -8.12% | ✗ | $15.6K |
| Jul 31, 2025 | Aug 4, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +85,000 | 0.67% | ✗ | $227.9K |
| Jul 29, 2025 | Jul 31, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 56.3 | +10,000 | 0.08% | ✗ | $28.2K |
| Jul 18, 2025 | Jul 22, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 75.0 | +100,000 | 0.79% | ✗ | $282K |
| Jun 27, 2025 | Jul 1, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +100,000 | 0.80% | ✗ | $239K |
| Jun 12, 2025 | Jun 16, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +250,000 | 2.04% | ✗ | $560K |
| Jun 10, 2025 | Jun 12, 2025 | WOLF DENNIS P | Director | Neutral | 90.0 | +40,983 | 38.33% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | Smith David V | Director | Neutral | 90.0 | +40,983 | 26.74% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | Singhvi Rahul | Director | Neutral | 90.0 | +40,983 | 42.66% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | Richards Christos | Director | Neutral | 90.0 | +40,983 | 92.83% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | PARKER H STEWART | Director | Neutral | 90.0 | +40,983 | 39.94% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | Martinborough Esther | Director | Neutral | 90.0 | +40,983 | 46.54% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | De Vre Raymond | Director | Neutral | 90.0 | +40,983 | 85.66% | ✗ | - |
| Jun 10, 2025 | Jun 12, 2025 | Collins Cynthia | Director | Neutral | 90.0 | +40,983 | 57.58% | ✗ | - |
| May 23, 2025 | May 28, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 100.0 | +2,325,000 | 23.43% | ✗ | $5.5M |
| Apr 30, 2025 | May 2, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 65.0 | +45,000 | 0.46% | ✗ | $104.1K |
| Apr 25, 2025 | Apr 29, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 65.0 | +25,000 | 0.25% | ✗ | $55.9K |
| Apr 15, 2025 | Apr 17, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +140,000 | 1.44% | ✗ | $298.8K |
| Apr 8, 2025 | Apr 9, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 82.5 | +100,000 | 1.04% | ✗ | $198.4K |
| Apr 1, 2025 | Apr 3, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +115,000 | 1.21% | ✗ | $271.8K |
| Mar 28, 2025 | Apr 1, 2025 | Collins Cynthia | Director | Neutral | 90.0 | +71,174 | 100.00% | ✗ | - |
| Apr 1, 2025 | Collins Cynthia | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 20, 2025 | Mar 24, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +92,930 | 0.99% | ✗ | $236.3K |
| Mar 13, 2025 | Mar 14, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +85,000 | 0.94% | ✗ | $216.2K |
| Mar 6, 2025 | Mar 10, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +100,000 | 1.12% | ✗ | $261.4K |
| Mar 4, 2025 | Mar 6, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +65,000 | 0.73% | ✗ | $172.3K |
| Feb 28, 2025 | Mar 4, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +195,000 | 2.24% | ✗ | $574.3K |
| Feb 10, 2025 | Feb 12, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +50,000 | 0.58% | ✗ | $205.5K |
| Feb 5, 2025 | Feb 7, 2025 | Norrett Kevin | COO | Neutral | 90.0 | +26,875 | 17.86% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | MOORE ALISON | Chief Technical Officer | Neutral | 90.0 | +26,875 | 18.07% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Erbez Georgia | CFO | Neutral | 90.0 | +26,875 | 53.75% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | DILLY STEPHEN GEORGE | Officer | Neutral | 90.0 | +88,750 | 15.19% | ✗ | - |
| Jan 30, 2025 | Jan 31, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 75.0 | +65,000 | 0.76% | ✗ | $283K |
| Jan 14, 2025 | Jan 16, 2025 | Richards Christos | Director | Neutral | 90.0 | +44,150 | 100.00% | ✗ | - |
| Jan 16, 2025 | Richards Christos | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 30, 2024 | Jan 2, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +45,000 | 0.53% | ✗ | $211K |
| Nov 7, 2024 | Nov 12, 2024 | De Vre Raymond | Director | Neutral | 90.0 | +47,846 | 100.00% | ✗ | - |
| Nov 12, 2024 | De Vre Raymond | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 25, 2024 | Oct 28, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 65.0 | +25,000 | 0.29% | ✗ | $72.7K |
| Oct 10, 2024 | Oct 10, 2024 | MOORE ALISON | Chief Technical Officer | Neutral | 90.0 | +50,000 | 50.66% | ✗ | - |
| Oct 10, 2024 | Oct 10, 2024 | Erbez Georgia | CFO | Neutral | 90.0 | +50,000 | 100.00% | ✗ | - |
| Oct 10, 2024 | Erbez Georgia | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 24, 2024 | Sep 26, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 82.5 | +85,000 | 1.01% | ✗ | $249.1K |
| Sep 20, 2024 | Sep 23, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 100.0 | +1,100,000 | 14.50% | ✗ | $3.3M |
| Sep 18, 2024 | Sep 19, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 72.5 | +61,000 | 0.81% | ✗ | $193K |
| Jun 11, 2024 | Jun 13, 2024 | Smith David V | Director | Neutral | 90.0 | +30,120 | 24.45% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | WOLF DENNIS P | Director | Neutral | 90.0 | +30,120 | 39.22% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Singhvi Rahul | Director | Neutral | 90.0 | +30,120 | 45.67% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | PARKER H STEWART | Director | Neutral | 90.0 | +30,120 | 41.56% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | MOORE ALISON | Director | Neutral | 90.0 | +30,120 | 43.92% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Martinborough Esther | Director | Neutral | 90.0 | +30,120 | 51.99% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Dorgan Byron L | Director | Neutral | 90.0 | +30,120 | 15.57% | ✗ | - |
| Jan 1, 2024 | Jan 2, 2024 | Ryali Sriram | CFO | Neutral | 90.0 | +52,350 | 42.41% | ✗ | - |
| Jan 1, 2024 | Jan 2, 2024 | Norrett Kevin | COO | Neutral | 90.0 | +52,350 | 53.36% | ✗ | - |
| Jan 1, 2024 | Jan 2, 2024 | Fitzgerald Margaret Nell | Officer | Neutral | 90.0 | +52,350 | 64.30% | ✗ | - |
| Jan 1, 2024 | Jan 2, 2024 | DILLY STEPHEN GEORGE | Officer | Neutral | 90.0 | +143,425 | 32.68% | ✗ | - |
| Nov 15, 2023 | Nov 17, 2023 | Dorgan Byron L | Director | Sell | 26.3 | -20,000 | -9.37% | ✗ | $42.2K |
| Nov 9, 2023 | Nov 14, 2023 | Singhvi Rahul | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 8, 2023 | Sep 12, 2023 | Ryali Sriram | CFO | Buy | 91.3 | +11,650 | 10.42% | ✗ | $19.9K |
| Sep 11, 2023 | Sep 12, 2023 | Norrett Kevin | COO | Buy | 91.3 | +9,000 | 10.10% | ✗ | $15.5K |
| Sep 8, 2023 | Sep 12, 2023 | Fitzgerald Margaret Nell | Officer | Buy | 91.3 | +11,834 | 17.01% | ✗ | $20.1K |
| Sep 8, 2023 | Sep 12, 2023 | DILLY STEPHEN GEORGE | Officer | Buy | 95.0 | +58,479 | 15.37% | ✗ | $101K |
| Jun 13, 2023 | Jun 15, 2023 | Aaker Jennifer | Director | Neutral | 90.0 | +34,602 | 109.47% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | Martinborough Esther | Director | Neutral | 90.0 | +34,602 | 148.31% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | WOLF DENNIS P | Director | Neutral | 90.0 | +34,602 | 82.00% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | Dorgan Byron L | Director | Neutral | 90.0 | +34,602 | 19.35% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | MOORE ALISON | Director | Neutral | 90.0 | +34,602 | 101.85% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | PARKER H STEWART | Director | Neutral | 90.0 | +34,602 | 91.35% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | Singhvi Rahul | Director | Neutral | 90.0 | +34,602 | 110.38% | ✗ | - |
| Jun 13, 2023 | Jun 15, 2023 | Smith David V | Director | Neutral | 90.0 | +23,329 | 23.37% | ✗ | - |
| Apr 17, 2023 | Apr 19, 2023 | NICOLS JOHN J | Director | Sell | 35.0 | -71,428 | -4.36% | ✓ | $299.3K |
| Mar 15, 2023 | Mar 17, 2023 | NICOLS JOHN J | Director | Sell | 35.0 | -71,428 | -4.36% | ✓ | $292.8K |
| Feb 8, 2023 | Mar 9, 2023 | Norrett Kevin | COO | Sell | 95.0 | +66,602 | 296.01% | ✗ | $77.2K |
| Feb 8, 2023 | Mar 9, 2023 | DILLY STEPHEN GEORGE | Officer | Sell | 97.5 | +233,925 | 159.70% | ✗ | $252.2K |
| Feb 8, 2023 | Mar 9, 2023 | Fitzgerald Margaret Nell | Officer | Sell | 95.0 | +61,586 | 769.83% | ✗ | $71.8K |
| Feb 23, 2023 | Feb 27, 2023 | NICOLS JOHN J | Director | Sell | 35.0 | -75,499 | -4.59% | ✓ | $385.9K |
| Feb 21, 2023 | Feb 21, 2023 | Norrett Kevin | COO | Neutral | 90.0 | +22,500 | 100.00% | ✗ | - |
| Feb 21, 2023 | Feb 21, 2023 | Fitzgerald Margaret Nell | Officer | Neutral | 90.0 | +8,000 | 100.00% | ✗ | - |
| Feb 21, 2023 | Feb 21, 2023 | DILLY STEPHEN GEORGE | Officer | Neutral | 90.0 | +112,500 | 331.14% | ✗ | - |
| Feb 10, 2023 | Feb 14, 2023 | Ryali Sriram | CFO | Neutral | 90.0 | +111,791 | 100.00% | ✗ | - |
| Feb 7, 2023 | Feb 9, 2023 | TAYLOR DEAN ROSS JR | Other | Sell | 47.5 | -1,224 | -3.08% | ✗ | $8K |
| Jan 25, 2023 | Ryali Sriram | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |