2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Brynjelsen Sean | CEO | 2,873,513 | Jun 5, 2025 |
| Krempa David | Chief Business Officer | 612,646 | Jun 16, 2025 |
| Gruber James R. | CFO | 204,753 | Aug 20, 2025 |
| Opaleye Management Inc. | 10% Owner | 85,000 | Jun 12, 2025 |
| Adams Jennifer McKie | — | 30,000 | Feb 15, 2024 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 3, 2026 | Feb 5, 2026 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 12, 2026 | Jan 14, 2026 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 12, 2026 | Jan 14, 2026 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 12, 2026 | Jan 14, 2026 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 12, 2026 | Jan 14, 2026 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 12, 2026 | Jan 14, 2026 | Erdogan-Trinkaus Ipek | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 1, 2026 | Jan 14, 2026 | BRYNJELSEN SEAN | CEO | Sell | 47.5 | -5,015 | -0.17% | ✗ | $77.2K |
| Jan 14, 2026 | Jan 14, 2026 | Krempa David | Chief Business Officer | Sell | 51.3 | -1,942 | -0.31% | ✗ | $30.3K |
| Jan 14, 2026 | Jan 14, 2026 | Gruber James R. | CFO | Sell | 46.3 | -2,293 | -1.06% | ✗ | $35.5K |
| Dec 12, 2025 | Dec 12, 2025 | Erdogan-Trinkaus Ipek | Chief Commercial Officer | Sell | 47.5 | -85 | -3.42% | ✗ | $1.4K |
| Dec 12, 2025 | Dec 12, 2025 | Krempa David | Chief Business Officer | Sell | 45.0 | -6,264 | -0.98% | ✗ | $106.5K |
| Dec 12, 2025 | Dec 12, 2025 | Gruber James R. | CFO | Sell | 42.5 | -4,542 | -2.06% | ✗ | $77.2K |
| Dec 12, 2025 | Dec 12, 2025 | BRYNJELSEN SEAN | CEO | Sell | 47.5 | -6,732 | -0.23% | ✗ | $113.3K |
| Aug 19, 2025 | Aug 20, 2025 | Gruber James R. | CFO | Sell | 20.0 | -41,713 | -9.23% | ✗ | $673.7K |
| Jun 12, 2025 | Jun 16, 2025 | Krempa David | Chief Business Officer | Sell | 20.0 | -34,000 | -5.26% | ✗ | $504.3K |
| Jun 10, 2025 | Jun 12, 2025 | Opaleye Management Inc. | 10% Owner | Buy | 65.0 | +7,930 | 0.28% | ✗ | $125.5K |
| Jun 3, 2025 | Jun 5, 2025 | BRYNJELSEN SEAN | CEO | Sell | 17.5 | -210,000 | -6.81% | ✗ | $3.6M |
| Jan 3, 2025 | Jan 6, 2025 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | Krempa David | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2025 | Jan 6, 2025 | Gruber James R. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 9, 2024 | Erdogan-Trinkaus Ipek | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 23, 2024 | Oct 25, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 65.0 | +10,000 | 0.36% | ✗ | $79.8K |
| Oct 4, 2024 | Oct 8, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 85.0 | +62,070 | 1.10% | ✗ | $434.1K |
| Oct 2, 2024 | Oct 4, 2024 | Krempa David | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 10, 2024 | Sep 12, 2024 | Opaleye Management Inc. | 10% Owner | Buy | 90.0 | +107,500 | 4.02% | ✗ | $504.9K |
| Sep 12, 2024 | Opaleye Management Inc. | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 13, 2024 | Feb 15, 2024 | Gruber James R. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | Krempa David | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 8, 2023 | Krempa David | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 3, 2023 | Mar 3, 2023 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2023 | Mar 3, 2023 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2023 | Mar 3, 2023 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2023 | Mar 3, 2023 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2023 | Mar 3, 2023 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2023 | Mar 3, 2023 | Gruber James R. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 22, 2022 | Sep 23, 2022 | BRYNJELSEN SEAN | CEO | Buy | 68.8 | +10,000 | 0.95% | ✗ | $21K |
| Jul 12, 2022 | Jul 18, 2022 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 12, 2022 | Jul 18, 2022 | Gruber James R. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 14, 2022 | Gruber James R. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 7, 2022 | Feb 28, 2022 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 7, 2022 | Feb 28, 2022 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 7, 2022 | Feb 28, 2022 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 7, 2022 | Feb 28, 2022 | Troutman William Wilson | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 7, 2022 | Feb 28, 2022 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 7, 2022 | Feb 28, 2022 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 17, 2021 | Nov 19, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 22.5 | -25,000 | -1.04% | ✗ | $116.7K |
| Nov 15, 2021 | Nov 17, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 32.5 | -15,438 | -0.62% | ✗ | $74.9K |
| Nov 5, 2021 | Nov 9, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 17.5 | -220,362 | -8.10% | ✗ | $1.4M |
| Nov 3, 2021 | Nov 5, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 17.5 | -202,200 | -6.92% | ✗ | $1.3M |
| Oct 8, 2021 | Oct 13, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -165,100 | -4.97% | ✗ | $830.7K |
| Aug 20, 2021 | Aug 20, 2021 | Troutman William Wilson | CFO | Buy | 91.3 | +5,000 | 27.74% | ✗ | $22.2K |
| Aug 20, 2021 | Aug 20, 2021 | BRYNJELSEN SEAN | CEO | Buy | 68.8 | +10,000 | 0.96% | ✗ | $43.2K |
| Aug 4, 2021 | Aug 6, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 17.5 | -604,500 | -16.37% | ✗ | $3.5M |
| Jun 15, 2021 | Jun 21, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -105,000 | -2.76% | ✗ | $847.4K |
| Jun 15, 2021 | Jun 17, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 20.0 | -105,000 | -2.76% | ✗ | $847.4K |
| Jun 3, 2021 | Jun 3, 2021 | BRYNJELSEN SEAN | CEO | Buy | 61.3 | +5,000 | 0.48% | ✗ | $29.8K |
| May 25, 2021 | May 27, 2021 | Opaleye Management Inc. | 10% Owner | Sell | 17.5 | -242,300 | -6.00% | ✗ | $2.1M |
| May 3, 2021 | May 5, 2021 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 3, 2021 | May 5, 2021 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 3, 2021 | May 5, 2021 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 3, 2021 | May 5, 2021 | Troutman William Wilson | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 3, 2021 | May 5, 2021 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 3, 2021 | May 5, 2021 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 17, 2021 | Adams Jennifer McKie | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 19, 2020 | Feb 16, 2021 | CASAMENTO CHARLES J | Director | Neutral | 27.5 | -3,500 | -4.87% | ✗ | - |
| Oct 16, 2020 | Oct 16, 2020 | Opaleye Management Inc. | 10% Owner | Buy | 100.0 | +400,000 | 10.99% | ✗ | $2.8M |
| Apr 6, 2020 | Opaleye Management Inc. | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 12, 2020 | Mar 16, 2020 | BAUM MARK L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2020 | Mar 16, 2020 | Troutman William Wilson | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2020 | Mar 16, 2020 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2020 | Mar 16, 2020 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2020 | Mar 16, 2020 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 12, 2020 | Mar 16, 2020 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 13, 2019 | Aug 13, 2019 | BRYNJELSEN SEAN | CEO | Buy | 61.3 | +5,000 | 0.48% | ✗ | $30.8K |
| Aug 9, 2019 | Aug 12, 2019 | CASAMENTO CHARLES J | Director | Buy | 86.3 | +3,500 | 5.12% | ✗ | $21.4K |
| May 20, 2019 | May 22, 2019 | BRYNJELSEN SEAN | CEO | Buy | 72.5 | +10,000 | 0.97% | ✗ | $79.3K |
| Feb 20, 2019 | Mar 8, 2019 | RIEDEL NORBERT G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 20, 2019 | Mar 8, 2019 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 20, 2019 | Mar 8, 2019 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 20, 2019 | Mar 8, 2019 | BAUM MARK L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 20, 2019 | Mar 8, 2019 | Troutman William Wilson | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 20, 2019 | Mar 8, 2019 | BRYNJELSEN SEAN | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 15, 2018 | Nov 15, 2018 | CASAMENTO CHARLES J | Director | Buy | 86.3 | +5,000 | 7.88% | ✗ | $30K |
| Nov 15, 2018 | Nov 15, 2018 | BRYNJELSEN SEAN | CEO | Buy | 82.5 | +10,000 | 1.00% | ✗ | $60K |
| Nov 15, 2018 | Nov 15, 2018 | MAIER PAUL V | Director | Buy | 86.3 | +5,000 | 9.13% | ✗ | $30K |
| Nov 15, 2018 | Nov 15, 2018 | RIEDEL NORBERT G | Director | Buy | 86.3 | +5,000 | 9.13% | ✗ | $30K |
| Nov 15, 2018 | Nov 15, 2018 | Troutman William Wilson | CFO | Buy | 91.3 | +5,000 | 100.00% | ✗ | $30K |
| Nov 15, 2018 | Nov 15, 2018 | BAUM MARK L | Director | Buy | 82.5 | +10,000 | 1.27% | ✗ | $60K |
| Nov 13, 2018 | CASAMENTO CHARLES J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 13, 2018 | MAIER PAUL V | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |